{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T14:57:16Z","timestamp":1758121036561},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":9561,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1983,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The development of acquired resistance in opisthorchiasis was studied in hamsters experimentally infected with <jats:italic>Opisthorchis viverrini<\/jats:italic>. The induction of protective immunity was attempted by first exposing adult female golden Syrian hamsters to 1,2 or 3 doses of infective metacercariae obtained from naturally infected cyprinoid fishes and then reinfecting them with 80 metacercariae. In other experiments, animals that were infected with 50 metacercariae were treated with praziquantel prior to being rechallenged in order to eliminate the flukes that had developed from the first infection. The effect of long-term chronic infections was also studied. Faecal egg counts were determined at weekly intervals from 4\u20135 weeks onwards. The animals were killed 2\u20133 months after the last infection for worm recovery, and terminal faecal egg output\/g faeces\/worm was calculated. The data showed that prior infection of animals with <jats:italic>O. viverrini<\/jats:italic> did not induce significant protective immunity against reinfection by the same parasite. Lack of protection was also noted in animals reinfected several times with small doses of metacercariae. However, under certain circumstances, prior infection could result in a significant reduction in the faecal egg output due to subsequent infection.<\/jats:p>","DOI":"10.1017\/s0031182000057231","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T16:36:26Z","timestamp":1244219786000},"page":"127-136","source":"Crossref","is-referenced-by-count":14,"title":["Attempts to induce protective immunity in hamsters against infection by a liver fluke of man (<i>Opisthorchis viverrini<\/i>)"],"prefix":"10.1017","volume":"86","author":[{"given":"S.","family":"Sirisinha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Tuti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tawatsin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Vichasri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. S.","family":"Upatham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Bunnag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000057231_ref009","first-page":"397","article-title":"A simple device for quantitative stool thick-smear technique in schistosomiasis","volume":"14","author":"Katz","year":"1972","journal-title":"Revista do Instituto de Medicina Tropical de Sao Paulo"},{"key":"S0031182000057231_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X0000657X"},{"key":"S0031182000057231_ref008","first-page":"439","article-title":"The immunological diagnosis of human opisthorchiasis and humoral immune response to opisthorchis infection in the hamster","volume":"63","author":"Janechaiwat","year":"1980","journal-title":"Journal of Medical Association of Thailand"},{"key":"S0031182000057231_ref004","first-page":"337","article-title":"Opisthorchis viverrini: liver changes in golden hamsters maintained on high and low protein diets","volume":"37","author":"Flavell","year":"1980","journal-title":"Acta tropica"},{"key":"S0031182000057231_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(81)90419-3"},{"key":"S0031182000057231_ref014","unstructured":"Tuti S. , Vichasri S. & Sirisinha S. (1982). In vitro studies on Opisthorchis viverrini: Maintenance of adult flukes in culture medium. Journal of Parasitology (in the Press)."},{"key":"S0031182000057231_ref017","first-page":"507","article-title":"Opisthorchis viverrini in Thailand: The life cycle and comparison with O.felineus","volume":"51","author":"Wykoff","year":"1965","journal-title":"Journal ofParasitology"},{"key":"S0031182000057231_ref016","first-page":"537","article-title":"Liver fluke infection and infestation in Southeast Asia","volume":"4","author":"Viranuvatti","year":"1972","journal-title":"Progress in Liver Diseases"},{"key":"S0031182000057231_ref002","first-page":"413","article-title":"Studies on the chemotherapy of human opisthorchiasis II. Minimum effective dose of praziquantel","volume":"12","author":"Bunnag","year":"1981","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"S0031182000057231_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(81)90421-1"},{"key":"S0031182000057231_ref007","first-page":"253","volume-title":"Proceedings of the 4th Southeast Asian Seminar on Parasitology and Tropical Medicine, Schistosomiasis and Other Snail-Transmitted Helminthiasis","author":"Harinasuta","year":"1969"},{"key":"S0031182000057231_ref010","first-page":"330","volume-title":"Biometry: The Principles and Practice of Statistics in Biological Research","author":"Sokal","year":"1969"},{"key":"S0031182000057231_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(69)90176-X"},{"key":"S0031182000057231_ref013","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1969.18.241"},{"key":"S0031182000057231_ref015","unstructured":"Vichasri S. (1981). Some biological studies between the liver fluke Opisthorchis viverrini and its host. M.Sc. thesis, Mahidol University, Bangkok, Thailand."},{"key":"S0031182000057231_ref018","doi-asserted-by":"publisher","DOI":"10.2307\/3276418"},{"key":"S0031182000057231_ref011","first-page":"215","article-title":"Hepatic carcinoma with opisthorchiasis","volume":"9","author":"Sonakul","year":"1978","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"S0031182000057231_ref001","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1978.27.787"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000057231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T19:39:24Z","timestamp":1558726764000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000057231\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,2]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,2]]}},"alternative-id":["S0031182000057231"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000057231","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,2]]}}}