{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:14:33Z","timestamp":1777590873975,"version":"3.51.4"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":7919,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1987,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>In an attempt to find possible targets for benzimidazole action in muscle-stage larvae of<jats:italic>Trichinella spiralis<\/jats:italic>, the effects of mebendazole and thiabendazole were tested<jats:italic>in vivo<\/jats:italic>by oral treatment of infested mice and<jats:italic>in vitro<\/jats:italic>by including these anthelmintics in an adequate maintenance medium containing decapsulated larvae. The effects of the anthelmintics on succinate dehydrogenase and fumarate reductase activities, measured in the mitochondrial fraction obtained from the<jats:italic>in vivo<\/jats:italic>- or<jats:italic>in vitro<\/jats:italic>-treated larvae showed that only thiabendazole causes significant inhibition of fumarate reductase activity. On the other hand, measurements of free glucose, glycogen reserves and soluble protein in the treated larvae indicate that<jats:italic>in vivo<\/jats:italic>, mebendazole and thiabendazole clearly diminish free glucose levels, although<jats:italic>in vitro<\/jats:italic>only mebendazole produces the same diminution. Both the glycogen and protein contents of the larvae remained unchanged after treatment<jats:italic>in vivo<\/jats:italic>or<jats:italic>in vitro.<\/jats:italic>The importance of these findings with regard to a possible site of action for mebendazole and thiabendazole is discussed.<\/jats:p>","DOI":"10.1017\/s0031182000057541","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T16:14:53Z","timestamp":1244218493000},"page":"61-70","source":"Crossref","is-referenced-by-count":23,"title":["The mode of action of some benzimidazole drugs on<i>Trichinella spiralis<\/i>"],"prefix":"10.1017","volume":"95","author":[{"given":"A. Criado","family":"Fornelio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. Rodriguez","family":"Caabeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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