{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T18:43:26Z","timestamp":1698605006557},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":7797,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1987,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Normal and T-cell deprived mice have been compared in their response to infection with<jats:italic>Schistosoma bovis<\/jats:italic>. The deprived mice survived longer than comparably infected, immunologically intact controls, despite an increased longevity of the adult<jats:italic>S. bovis<\/jats:italic>worms in the former animals giving rise to higher tissue egg densities. The reduced pathology in deprived mice was due to inhibition of T-cell dependent granuloma formation around tissue-bound schistosome eggs, with concomitantly decreased tissue disruption as evidenced by smaller spleens and lower circulating transaminase concentrations. These observations on<jats:italic>S. bovis<\/jats:italic>contrast with the greater morbidity and earlier mortality induced by<jats:italic>S. mansoni<\/jats:italic>in T-cell deprived mice, the latter due to an hepatotoxic potential of<jats:italic>S. mansoni<\/jats:italic>eggs that is expressed in the absence of the host immune response. The absence of hepatocyte damage around<jats:italic>S. bovis<\/jats:italic>eggs in deprived mice indicates that this schistosome lacks such a toxin, and this could explain why during<jats:italic>S. bovis<\/jats:italic>infection synthesis of the two acute-phase proteins, complement C3 and serum amyloid P-component (SAP) here seemed less T-dependent than has previously been found during<jats:italic>S. mansoni<\/jats:italic>infection of mice. In a time-course experiment the hypergammaglobulinaemia induced by<jats:italic>S. bovis<\/jats:italic>, and the specific IgG antibody response against egg antigens were significantly T-cell dependent during the early stages of patency. Similarly, in most experiments assayed once between 9 and 11 weeks after<jats:italic>S. bovis<\/jats:italic>infection, deprived mice had significantly reduced hypergammaglobulinaemias, and reduced specific IgM and IgG antibody responses against both worm and egg antigens.<\/jats:p>","DOI":"10.1017\/s0031182000057942","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T16:12:44Z","timestamp":1244218364000},"page":"517-530","source":"Crossref","is-referenced-by-count":9,"title":["The response to<i>Schistosoma bovis<\/i>in normal and T-cell deprived mice"],"prefix":"10.1017","volume":"95","author":[{"given":"H. M.","family":"Murare","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Agnew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn","family":"Baltz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. B.","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Doenhoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000057942_ref017","first-page":"343","article-title":"Serum protein concentrations during Schistosoma mansoni infection in intact and T-cell deprived mice. II. 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Antigen sequestration and destruction in the schistosome pseudotubercle","volume":"45","author":"von Lichtenberg","year":"1964","journal-title":"American Journal of Pathology"},{"key":"S0031182000057942_ref018","first-page":"369","article-title":"Studies in vivo of cobra factor and murine C3","volume":"28","author":"Pepys","year":"1975","journal-title":"Immunology"},{"key":"S0031182000057942_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(81)90013-4"},{"key":"S0031182000057942_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(81)90012-2"},{"key":"S0031182000057942_ref023","first-page":"711","article-title":"Host response to eggs of S. mansoni. I. 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