{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:30:46Z","timestamp":1793410246671,"version":"4.5.0"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":7127,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1989,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The excretions-secretions (E-S) of<jats:italic>Acanthocheilonema viteae<\/jats:italic>consist mainly of one product, molecular weight 62 kDa. This molecule is synthesized during the vertebrate phase of the parasite life-cycle and is first detectable in the E-S of L4 parasites. It is cross-reactive with E-S of human filarial parasites as a consequence of possessing a phosphorylcholine (PC) moiety. The 62 kDa molecule has been employed as a model for the study of the origin and fate of filarial E-S. Immunohistological analysis has shown the molecule to be located predominantly in the parasite gut. Transplantation of adult female [S] methionine pulsed worms into uninfected jirds resulted in the radio-labelled secreted 62 kDa antigen being detected in the bloodstream within 4 h by SDS\u2013PAGE\/immunoprecipitation analysis. The systemic half-life of the molecule as estimated by clearance of injected, purified I-labelled material was measured in naive and infected jird hosts.<\/jats:p>","DOI":"10.1017\/s0031182000058686","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:48:17Z","timestamp":1244213297000},"page":"229-239","source":"Crossref","is-referenced-by-count":53,"title":["Origin, kinetics of circulation and fate<i>in vivo<\/i>of the major excretory\u2013secretory product of<i>Acanthocheilonema viteae<\/i>"],"prefix":"10.1017","volume":"99","author":[{"given":"W.","family":"Harnett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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