{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T15:10:35Z","timestamp":1685027435182},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":7066,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1989,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Naive CBA\/Ca mice and CBA\/Ca mice infected 12 weeks previously with 20 normal cercariae of<jats:italic>Schistosoma mansoni<\/jats:italic>were challenged percutaneously with isotopically labelled parasites. Challenge worm migration was followed, in 5 separate experiments, by means of compressed organ autoradiography. In three experiments, 43.1 % of challenge parasites did not arrive in the lungs of infected mice on day 6 as compared to 7.7 % in naive controls, thereby indicating that pre-lung sites constitute the first barrier in resistance to reinfection. A further 15% of the challenge worm burden was lost in the lungs or en route to the liver in the immune animals, and portal perfusion revealed that 25.4% of the challenge was lost in the liver. Two other experiments revealed no comparable phases of pre-liver attrition however; instead resistance was only evident at final perfusion on days 28 or 35. These data reveal the variable generation of specific acquired immunity in mice harbouring a chronic schistosome infection and thus clarify current discrepancies in the literature. The results are discussed in relation to documented evidence for the nature of specific and non-specific immune mechanisms reported to operate at different sites in the infection model of schistosomiasis mansoni.<\/jats:p>","DOI":"10.1017\/s0031182000059072","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:45:46Z","timestamp":1244213146000},"page":"357-364","source":"Crossref","is-referenced-by-count":0,"title":["Variable generation of specific acquired resistance in CBA\/Ca mice chronically infected with schistosomiasis mansoni"],"prefix":"10.1017","volume":"99","author":[{"given":"V. S.","family":"Delgado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Mclaren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000059072_ref028","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000000755"},{"key":"S0031182000059072_ref008","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000044826"},{"key":"S0031182000059072_ref024","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1981.tb00382.x"},{"key":"S0031182000059072_ref010","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000057395"},{"key":"S0031182000059072_ref030","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1969.tb15904.x"},{"key":"S0031182000059072_ref014","doi-asserted-by":"publisher","DOI":"10.1084\/jem.142.4.805"},{"key":"S0031182000059072_ref019","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1985.tb00477.x"},{"key":"S0031182000059072_ref021","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000058492"},{"key":"S0031182000059072_ref015","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1983.32.785"},{"key":"S0031182000059072_ref006","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1984.33.89"},{"key":"S0031182000059072_ref001","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1981.30.815"},{"key":"S0031182000059072_ref029","first-page":"101","article-title":"The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of adult worms","volume":"92","author":"Smithers","year":"1965","journal-title":"Parasitology"},{"key":"S0031182000059072_ref032","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200008166X"},{"key":"S0031182000059072_ref031","first-page":"479","article-title":"Eosinophil-enriched inflammatory response to schistosomula in the skin of mice immune to Schistosoma mansoni","volume":"84","author":"Von Lichtenberg","year":"1976","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"S0031182000059072_ref025","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1980.29.1268"},{"key":"S0031182000059072_ref027","first-page":"527","volume-title":"Immunology of Parasitic Infections","author":"Smithers","year":"1982"},{"key":"S0031182000059072_ref004","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1981.30.806"},{"key":"S0031182000059072_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(83)90002-4"},{"key":"S0031182000059072_ref017","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1986.35.332"},{"key":"S0031182000059072_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(84)90077-8"},{"key":"S0031182000059072_ref033","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/127.5.595"},{"key":"S0031182000059072_ref013","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1987.tb00527.x"},{"key":"S0031182000059072_ref023","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(80)90022-3"},{"key":"S0031182000059072_ref035","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1983.tb00776.x"},{"key":"S0031182000059072_ref005","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1984.33.97"},{"key":"S0031182000059072_ref016","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.4049\/jimmunol.136.7.2644","article-title":"Passive transfer with serum and IgG antibodies of irradiated cercariaeinduced resistance against Schistosoma mansoni in mice","volume":"136","author":"Mangold","year":"1986","journal-title":"Journal of Immunology"},{"key":"S0031182000059072_ref018","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000052446"},{"key":"S0031182000059072_ref034","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000063484"},{"key":"S0031182000059072_ref007","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1978.27.957"},{"key":"S0031182000059072_ref002","doi-asserted-by":"publisher","DOI":"10.1007\/BF00390119"},{"key":"S0031182000059072_ref011","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.4049\/jimmunol.133.3.1587","article-title":"Defective vaccine-induced immunity to Schistosoma mansoni in P strain mice. II. Analysis of cellular responses","volume":"133","author":"James","year":"1984","journal-title":"Journal of Immunology"},{"key":"S0031182000059072_ref020","first-page":"233","volume-title":"The Biology of Schistosomes","author":"Mclaren","year":"1987"},{"key":"S0031182000059072_ref012","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.4049\/jimmunol.137.12.3959","article-title":"Defective vaccine-induced resistance to Schistosoma mansoni in P strain mice. III. Specificity of the associated defect in cellmediated immunity","volume":"127","author":"James","year":"1986","journal-title":"Journal of Immunology"},{"key":"S0031182000059072_ref026","first-page":"133","article-title":"The demonstration of immunity to Schistosoma mansoni in the mouse and its correlation with in vitro findings","volume":"47","author":"Smithers","year":"1982","journal-title":"Pontificiae Academiae Scientiarum Scripta Varia"},{"key":"S0031182000059072_ref022","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1987.tb00537.x"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000059072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T14:32:19Z","timestamp":1685025139000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000059072\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,12]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,12]]}},"alternative-id":["S0031182000059072"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000059072","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,12]]}}}