{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T18:26:18Z","timestamp":1743791178684},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":7066,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1989,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>129\/Ola mice resemble WEHI 129J mice in that around 70% of the individuals in any given population resist a primary infection with<jats:italic>Schistosoma mansoni<\/jats:italic>. Squashed-organ autoradiographic tracking of [Se]selenomethionine-labelled parasites has shown that the kinetics of worm migration in 129\/Ola mice follows the expected pattern, and that all rodents harbour essentially similar numbers of worms on day 14 post-infection. Combined lung and liver worm recovery techniques have revealed, however, that segregation of mice into \u2018permissive\u2019 and \u2018non-permissive\u2019 individuals can first be detected on day 20. \u2018Non-permissive\u2019 mice are characterized by the absence of schistosome eggs at all times in the liver parenchyma and, in consequence, lack the attendant manifestations of pathology; they do, however, harbour a few stunted worms in the liver and significant numbers of adult schistosomes in the pulmonary vasculature. Histological analysis of sectioned lung tissue from such animals indicates that some lung-located schistosomes feed, pair and lay eggs. Nevertheless, eosinophil-enriched inflammatory reactions develop around such worms and the parasites themselves exhibit various manifestations of trauma, ranging from minor vacuolation to gut herniation and extrusion. The phenomenon of \u2018non-permissiveness\u2019 thus involves retardation of worm development in the liver and, in consequence, relocation of the parasites to the lungs, where they become subject to host effector responses.<\/jats:p>","DOI":"10.1017\/s0031182000059084","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:45:46Z","timestamp":1244213146000},"page":"365-375","source":"Crossref","is-referenced-by-count":12,"title":["<i>Schistosoma mansoni<\/i>: evidence that \u2018non-permissiveness\u2019 in 129\/Ola mice involves worm relocation and attrition in the lungs"],"prefix":"10.1017","volume":"99","author":[{"given":"A. A. F.","family":"Elsaghier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. M.","family":"Knopf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. F.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Mclaren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000059084_ref004","doi-asserted-by":"publisher","DOI":"10.2307\/3281382"},{"key":"S0031182000059084_ref011","doi-asserted-by":"publisher","DOI":"10.2307\/3281655"},{"key":"S0031182000059084_ref009","first-page":"357","article-title":"The isoenzymes of glutathione transferase","volume":"57","author":"Mannervik","year":"1985","journal-title":"Advances in Enzymology"},{"key":"S0031182000059084_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(84)90138-X"},{"key":"S0031182000059084_ref015","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/j.1460-2075.1988.tb02834.x","article-title":"The glutathione transferase activity and tissue distribution of a cloned Mr 28K protective antigen of Schistosoma mansoni","volume":"3","author":"Taylor","year":"1988","journal-title":"EMBO Journal"},{"key":"S0031182000059084_ref010","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1982.tb00426.x"},{"key":"S0031182000059084_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(87)90082-8"},{"key":"S0031182000059084_ref003","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1987.56"},{"key":"S0031182000059084_ref007","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1987.tb00527.x"},{"key":"S0031182000059084_ref002","doi-asserted-by":"publisher","DOI":"10.1007\/BF00390119"},{"key":"S0031182000059084_ref005","doi-asserted-by":"crossref","unstructured":"Holy J. M. , O'Leary K. A. , Oaks J. A. & Tracy J. W. (1989). Immunocytochemical localization of the major glutathione S-transferases in adult Schistosoma mansoni. (in the press).","DOI":"10.2307\/3282764"},{"key":"S0031182000059084_ref012","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.22.8703"},{"key":"S0031182000059084_ref013","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000000755"},{"key":"S0031182000059084_ref014","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000086248"},{"key":"S0031182000059084_ref008","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1983.32.785"},{"key":"S0031182000059084_ref016","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1986.36"},{"key":"S0031182000059084_ref017","first-page":"115","volume-title":"The Biology of Schistosomes: From Genes to Latrines","author":"Wilson","year":"1987"},{"key":"S0031182000059084_ref001","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1128\/IAI.55.5.1163-1169.1987","article-title":"Helper T cells induced by a purified 28-kilodalton antigen of Schistosoma mansoni protect rats against infection","volume":"55","author":"Auriault","year":"1987","journal-title":"Infection and Immunity"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000059084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T06:49:51Z","timestamp":1589870991000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000059084\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,12]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,12]]}},"alternative-id":["S0031182000059084"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000059084","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,12]]}}}