{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T09:42:59Z","timestamp":1710409379927},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":6397,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1991,10]]},"abstract":"<jats:p>A number of authors have demonstrated that the schistosomicidal compound, Praziquantel (Pzq), depends for its action upon the immune status of the host (Sabah<jats:italic>et al.<\/jats:italic>1985; Brindley &amp; Sher, 1987; Doenhoff<jats:italic>et al.<\/jats:italic>1987). We have attempted to define the synergistic interaction between immuno- and chemotherapy further, using the murine irradiated vaccine model of schistosomiasis mansoni. In vaccinated mice, resistance operates in the skin but not the lungs; drug targeted towards lung-stage worms exacerbates lung-phase immunity, however, as depicted by the increased number and size of inflammatory reactions in the pulmonary tissues. Parasites are often found trapped within such foci. In the present investigation, light and ultrastructural studies have been utilized to examine the nature and extent of damage inflicted upon lung-stage larvae recovered from day 6 Pzq-treated vaccinated mice. Such studies have revealed that damage involves muscle disorganization, internal disruption and occasionally, loss of the tegument; in the latter case, cells are often seen attached to the denuded lung worms. To identify the crucial cellular effector cell(s) involved in the synergy between immuno- and chemotherapy, cell depletion studies have been performed<jats:italic>in vivo<\/jats:italic>. It would appear from these experiments that eosinophils or lymphocytes rather than neutrophils or macrophages are important effector cells in this synergy. Histological studies argue in favour of eosinophils being the key effector cells.<\/jats:p>","DOI":"10.1017\/s0031182000059497","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:29:25Z","timestamp":1244212165000},"page":"207-224","source":"Crossref","is-referenced-by-count":5,"title":["<i>Schistosoma mansoni<\/i>: larval damage and role of effector cell(s) in the synergy between vaccine immunity and Praziquantel treatment"],"prefix":"10.1017","volume":"103","author":[{"given":"K. P.","family":"Piper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. F.","family":"Mott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Hockley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"McLaren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000059497_ref021","doi-asserted-by":"publisher","DOI":"10.1084\/jem.138.3.625"},{"key":"S0031182000059497_ref040","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200008166X"},{"key":"S0031182000059497_ref033","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(82)90154-7"},{"key":"S0031182000059497_ref025","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1987.tb00537.x"},{"key":"S0031182000059497_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(82)90008-9"},{"key":"S0031182000059497_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60268-9"},{"key":"S0031182000059497_ref014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1989.tb00670.x"},{"key":"S0031182000059497_ref006","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4049\/jimmunol.139.1.215","article-title":"The chemotherapeutic effect of praziquantel against Schistosoma mansoni is dependent on host antibody response","volume":"139","author":"Brindley","year":"1987","journal-title":"Journal of Immunology"},{"key":"S0031182000059497_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(85)90020-8"},{"key":"S0031182000059497_ref001","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1987.37.570"},{"key":"S0031182000059497_ref036","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000053920"},{"key":"S0031182000059497_ref031","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197203000-00026"},{"key":"S0031182000059497_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(87)90360-9"},{"key":"S0031182000059497_ref039","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000081658"},{"key":"S0031182000059497_ref002","first-page":"395","volume-title":"In Vitro Methods in Cell Mediated and Tumor Immunity","author":"Allison","year":"1976"},{"key":"S0031182000059497_ref034","doi-asserted-by":"publisher","DOI":"10.1007\/BF00934012"},{"key":"S0031182000059497_ref022","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1984.tb02923.x"},{"key":"S0031182000059497_ref005","doi-asserted-by":"publisher","DOI":"10.1007\/BF00927527"},{"key":"S0031182000059497_ref009","unstructured":"Delgado V. S. (1989). Comparative studies of immune expression in the mouse and guinea pig models of Schistosomiasis mansoni and of the inter-relationship between immunity and drug therapy. 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