{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T19:48:49Z","timestamp":1766951329903},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":7369,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1989,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The survival of <jats:italic>Heligmosomoides polygyrus<\/jats:italic> was monitored during primary infections in female C<jats:sub>57<\/jats:sub>Bl<jats:sub>10<\/jats:sub>, NIH and BALB\/c mice at low and high intensities of infection. Survivorship curves were fitted for each data set and analysed. C<jats:sub>57<\/jats:sub>Bl<jats:sub>10<\/jats:sub> mice, given either low or high intensities of infection, harboured parasites for 28\u201337 weeks, heavier infections surviving marginally but significantly longer. Essentially the survivorship curves of <jats:italic>H. polygyrus<\/jats:italic> in C<jats:sub>57<\/jats:sub>Bl<jats:sub>10<\/jats:sub> mice could be accounted for by senility, the increased probability of worms with a longer life-span occurring at high infection intensities and, possibly, by a contribution from host-protective immune mechanisms in the terminal stages of infection. The pattern of survivorship was different in NIH and BALB\/c mice. NIH mice showed weak but significant density-dependent suppression of parasite loss and infections in this strain did not exceed 27\u00b75 weeks in duration. Primary infections in BALB\/c mice were briefer still and showed marked dependence on parasite density. Thus low-level infections lasted 10\u201315 weeks whereas heavier infections survived for 21\u201334 weeks. The data suggested that both strains developed host-protective responses to adult <jats:italic>H. polygyrus<\/jats:italic> and that parasite survival was curtailed earlier than would be expected if senility alone was involved. The hybrid strains (C<jats:sub>57<\/jats:sub>Bl<jats:sub>10<\/jats:sub> \u00d7 NIH)F1 and (B10G \u00d7 NIH)F1 both expelled <jats:italic>H. polygyrus<\/jats:italic> in a dose-dependent manner, worm loss commencing within 10 weeks of infection. In some experiments worm loss was clearly evident by weeks 4 and 6. These hybrid strains showed gene complementation in that adult worms were cleared considerably earlier than in parental strains.<\/jats:p>","DOI":"10.1017\/s0031182000059758","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T12:04:53Z","timestamp":1244203493000},"page":"115-124","source":"Crossref","is-referenced-by-count":58,"title":["Immunological relationships during primary infection with <i>Heligmosomoides polygyrus<\/i> (<i>Nematospiroides dubius<\/i>): dose-dependent expulsion of adult worms"],"prefix":"10.1017","volume":"98","author":[{"given":"M.","family":"Robinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Wahid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Behnke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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