{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:46:34Z","timestamp":1786999594782,"version":"build-2736575974"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":6336,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1991,12]]},"abstract":"<jats:p>\n                    In haemolymph of\n                    <jats:italic>Lymnaea stagnalis<\/jats:italic>\n                    , parasitized with the digenetic trematode parasite\n                    <jats:italic>Trichobilharzia ocellata<\/jats:italic>\n                    , a neuropeptide (schistosomin) occurs which antagonizes female gonadotropic hormones, e.g. calfluxin (CaFl). By means of an ultracytochemical hormone-assay, the CaFl assay, it was demonstrated that the occurrence of schistosomin is a general phenomenon in schistosome-infected freshwater snails. Haemolymph of the schistosomiasis-transmitting snail species\n                    <jats:italic>Biomphalaria glabrata<\/jats:italic>\n                    and\n                    <jats:italic>B. pfeifferi<\/jats:italic>\n                    , parasitized with\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    , also appeared to contain an antagonizing factor, i.e. schistosomin. In contrast, in haemolymph of\n                    <jats:italic>L. stagnalis<\/jats:italic>\n                    parasitized with\n                    <jats:italic>Diplostomum spathaceum<\/jats:italic>\n                    (Diplostomatidae) no schistosomin could be found. This suggests that schistosomin may only occur in snails infected with parasites belonging to the Schistosomatidae. The effect of schistosomin is rather specific. Haemolymph of\n                    <jats:italic>B. glabrata<\/jats:italic>\n                    parasitized with\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    had not the capacity to inhibit the response to CaFl in the target organs for CaFl, the albumen glands of\n                    <jats:italic>L. stagnalis<\/jats:italic>\n                    and\n                    <jats:italic>Bulinus truncatus<\/jats:italic>\n                    . The same holds true for haemolymph of infected\n                    <jats:italic>L. stagnalis<\/jats:italic>\n                    : it did not inhibit the CaFl response in glands of\n                    <jats:italic>B. glabrata<\/jats:italic>\n                    and\n                    <jats:italic>B. truncatus<\/jats:italic>\n                    and even not in those of a related species (\n                    <jats:italic>L. ovata<\/jats:italic>\n                    ). Schistosomins in haemolymph of infected\n                    <jats:italic>B. glabrata<\/jats:italic>\n                    and\n                    <jats:italic>B. pfeifferi<\/jats:italic>\n                    , on the other hand, seem more related. Both appeared to inhibit the hormone response in glands of the two\n                    <jats:italic>Biomphalaria<\/jats:italic>\n                    species studied. The results indicate that schistosomin in haemolymph of schistosome-infected pulmonate snails, although functionally related, may differ structurally.\n                  <\/jats:p>","DOI":"10.1017\/s0031182000059886","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T10:25:32Z","timestamp":1244197532000},"page":"371-378","source":"Crossref","is-referenced-by-count":13,"title":["The occurrence of schistosomin, an antagonist of female gonadotropic hormones, is a general phenomenon in haemolymph of schistosome-infected freshwater snails"],"prefix":"10.1017","volume":"103","author":[{"given":"M.","family":"De Jong-Brink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Elsaadany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000059886_ref021","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2011(85)90064-3"},{"key":"S0031182000059886_ref020","doi-asserted-by":"crossref","first-page":"22329","DOI":"10.1016\/S0021-9258(18)45709-2","article-title":"\u03b4-bag cell peptide from the egg-laying hormone precursor of Aplysia: processing primary structure and biological activity","volume":"265","author":"Nagle","year":"1990","journal-title":"Journal of Biological Chemistry"},{"key":"S0031182000059886_ref015","volume-title":"Molluscan Neurobiology","author":"Hordijk","year":"1991"},{"key":"S0031182000059886_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60108-6"},{"key":"S0031182000059886_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(90)90094-3"},{"key":"S0031182000059886_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(88)90110-5"},{"key":"S0031182000059886_ref019","doi-asserted-by":"publisher","DOI":"10.1163\/002829684X00236"},{"key":"S0031182000059886_ref009","first-page":"257","article-title":"Morphometrical, enzyme cytochemical and biochemical studies on the secretory activity of a female accessory sex gland (albumen gland) of the freshwater snail Lymnaea stagnalis","volume":"90","author":"Dictus","year":"1987","journal-title":"Koninklijke Nederlandse Akademie van Wetenschappen"},{"key":"S0031182000059886_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(88)90112-9"},{"key":"S0031182000059886_ref003","first-page":"163","volume-title":"Advances in Invertebrate Reproduction","volume":"4","author":"De Jong-Brink","year":"1986"},{"key":"S0031182000059886_ref013","first-page":"255","volume-title":"Current Aspects of the Neurosciences","author":"Geraerts","year":"1990"},{"key":"S0031182000059886_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(89)90012-X"},{"key":"S0031182000059886_ref012","doi-asserted-by":"publisher","DOI":"10.1007\/BF01989899"},{"key":"S0031182000059886_ref027","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-305X(79)80004-X"},{"key":"S0031182000059886_ref007","first-page":"141","volume-title":"Advances in Invertebrate Reproduction","volume":"5","author":"De Jong-Brink","year":"1990"},{"key":"S0031182000059886_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(71)90103-2"},{"key":"S0031182000059886_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(83)90164-8"},{"key":"S0031182000059886_ref026","doi-asserted-by":"publisher","DOI":"10.1007\/BF00927722"},{"key":"S0031182000059886_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(87)90130-4"},{"key":"S0031182000059886_ref001","volume-title":"Statistics in Biology","volume":"1","author":"Bliss","year":"1967"},{"key":"S0031182000059886_ref018","doi-asserted-by":"publisher","DOI":"10.1163\/002829672X00013"},{"key":"S0031182000059886_ref032","doi-asserted-by":"publisher","DOI":"10.2307\/1267462"},{"key":"S0031182000059886_ref024","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000060376"},{"key":"S0031182000059886_ref025","doi-asserted-by":"publisher","DOI":"10.1177\/30.7.6179981"},{"key":"S0031182000059886_ref028","volume-title":"Biometry","author":"Sokal","year":"1969"},{"key":"S0031182000059886_ref029","volume-title":"Principles and Procedures of Statistics","author":"Steel","year":"1960"},{"key":"S0031182000059886_ref031","doi-asserted-by":"crossref","first-page":"4184","DOI":"10.1523\/JNEUROSCI.08-11-04184.1988","article-title":"Isolation, characterization and evolutionary aspects of a cDNA clone encoding multiple neuropeptides involved in the stereotyped egg-laying behaviour of the freshwater snail Lymnaea stagnalis","volume":"8","author":"Vreugdenhil","year":"1988","journal-title":"Journal of Neurosciences"},{"key":"S0031182000059886_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(88)90116-5"},{"key":"S0031182000059886_ref022","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(87)90200-0"},{"key":"S0031182000059886_ref030","unstructured":"Van Heumen W. R. A. (1991). Immuno-electron microscopy of synthesis, processing, storage and release of neuropeptides in molluscs. Ph.D. thesis, University of Utrecht: Drukkerij Elinkwijk B.V."},{"key":"S0031182000059886_ref014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1991.tb15685.x"},{"key":"S0031182000059886_ref023","doi-asserted-by":"publisher","DOI":"10.1007\/BF00935429"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000059886","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T05:01:30Z","timestamp":1710392490000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000059886\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,12]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1991,12]]}},"alternative-id":["S0031182000059886"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000059886","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,12]]}}}