{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T18:54:23Z","timestamp":1698000863229},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":7004,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1990,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study addresses the humoral and cellular basis of specific acquired immunity in the guinea-pig irradiated vaccine model of schistosomiasis mansoni. Rodents vaccinated with 500 gamma-irradiated cercariae and then splenectomized 4\u00b75 weeks later showed a 33% reduction in resistance to challenge as compared to vaccinated animals or vaccinated\/sham splenectomized controls. Serum harvested from once vaccinated individuals conferred modest levels of resistance upon naive recipients in some experiments, but transfer was not achieved consistently. Serum from vaccinated and thrice boosted rodents (Vbbb) routinely transferred around 45% immunity, however, provided it was given in 4 ml aliquots on day 9 post-challenge; Vbbb serum thus transferred 50% of donor immunity. Interestingly, multiple doses of this protective serum given on and either side of day 9 did not enhance the protection achieved with a single 4 ml aliquot. Neither peripheral lymph node cells nor splenocytes from the polyvaccinated serum donors were able to transfer resistance to recipient guinea-pigs and they failed to augment the protection achieved with Vbbb serum. Food-pad testing revealed no correlation between delayed hypersensitivity responses and immunity to challenge in vaccinated guinea-pigs. Although polyvaccine guinea-pig serum successfully protected homologous recipients, it failed to protect mice when administered either at the time of challenge (the optimal schedule for transfer of polyvaccine mouse serum), or around day 9 (the optimal schedule for guinea-pigs). Similarly, guinea-pigs could not be protected with polyvaccine rat serum that conferred 75% resistance upon naive recipient rats.<\/jats:p>","DOI":"10.1017\/s0031182000060091","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:41:53Z","timestamp":1244212913000},"page":"35-44","source":"Crossref","is-referenced-by-count":5,"title":["<i>Schistosoma mansoni:<\/i>analysis of the humoral and cellular basis of resistance in guinea-pigs vaccinated with radiation-attenuated cercariae"],"prefix":"10.1017","volume":"100","author":[{"given":"D. J.","family":"McLaren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. S.","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. V.","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000060091_ref016","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000000755"},{"key":"S0031182000060091_ref008","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.4049\/jimmunol.136.7.2644","article-title":"Passive transfer with serum and IgG antibodies of irradiated cercariae-induced resistance against Schistosoma mansoni in mice","volume":"136","author":"Mangold","year":"1986","journal-title":"Journal of Immunology"},{"key":"S0031182000060091_ref004","first-page":"252","article-title":"Immunity to schistosomiasis mansoni in guinea-pigs vaccinated with radiation-attenuated cercariae: I. Humoral responses against skin-stage schistosomula","volume":"67","author":"Gordon","year":"1987","journal-title":"Clinical and Experimental Immunology"},{"key":"S0031182000060091_ref012","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000058492"},{"key":"S0031182000060091_ref009","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1985.tb00477.x"},{"key":"S0031182000060091_ref018","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000081658"},{"key":"S0031182000060091_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000056705"},{"key":"S0031182000060091_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000057395"},{"key":"S0031182000060091_ref013","unstructured":"Pearce E. J. (1983). Studies on immunity to Schistosoma mansoni in the guinea pig. Ph.D. thesis, Brunei University."},{"key":"S0031182000060091_ref001","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1987.37.570"},{"key":"S0031182000060091_ref011","first-page":"233","volume-title":"The Biology of Schistosomes","author":"McLaren","year":"1987"},{"key":"S0031182000060091_ref002","article-title":"Evidence for enhancement of IgG1 subclass expression in mice polyvaccinated with radiation-attenuated cercariae of Schistosoma mansoni and role of this isotype in serum transferred immunity","author":"Delgado","year":"1989","journal-title":"Parasite Immunology"},{"key":"S0031182000060091_ref006","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.4049\/jimmunol.136.10.3872","article-title":"Induction of protective immunity against Schistosoma mansoni by a non-living vaccine. III. 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