{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:20:43Z","timestamp":1761862843747},"reference-count":51,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":7004,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1990,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Naive CBA\/Ca mice and CBA\/Ca mice vaccinated 4 weeks previously with radiation-attenuated cercariae of<jats:italic>Schistosoma mansoni<\/jats:italic>were subjected to 550 rad of whole body (gamma) irradiation and then challenged 3 days laterwith normal cercariae. The perfusion recovery data showed that this procedure reduced theprimary worm burden in naive mice by 22% and the challenge worm burden in vaccinated mice by 82%. Irradiation also ablated the peripheral blood leucocytes of both mouse groups by 90%\u2013100% at the time of challenge. Histological data revealed that such treatment caused a dramatic change in number, size and leucocyte composition of cutaneous inflammatory skin reactions that characterize challenged vaccinated mice and are known to entrap invading larvae; cutaneous eosinophils were preferentially abolished by this treatment. Polyvaccine mouse serum that conferred protection passively upon naive recipient mice, failed to protect naive\/irradiated mice when administered by the same protocol. Distraction of macrophages by treatment of mice with silica did not affect the establishment of a primary worm burden and reduced the protection exhibited by vaccinated mice by only 16%. These data indicate that radio-sensitive cells are important to both innate and specific acquired resistance in this mouse model and that macrophages contribute only marginally to the expression of vaccine immunity.<\/jats:p>","DOI":"10.1017\/s0031182000060108","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:41:53Z","timestamp":1244212913000},"page":"45-56","source":"Crossref","is-referenced-by-count":8,"title":["Evidence that radio-sensitive cells are central to skin-phase protective immunity in CBA\/Ca mice vaccinated with radiation-attenuated cercariae of<i>Schistosoma mansoni<\/i>as well as in naive mice protected with vaccine serum"],"prefix":"10.1017","volume":"100","author":[{"given":"V. S.","family":"Delgado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"McLaren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000060108_ref051","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1983.tb00776.x"},{"key":"S0031182000060108_ref048","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200008166X"},{"key":"S0031182000060108_ref047","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000081658"},{"key":"S0031182000060108_ref045","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000086248"},{"key":"S0031182000060108_ref040","first-page":"107","article-title":"The macrophage in allograft immunity. Effect of silica as a specific macrophage toxin","volume":"5","author":"Pearsall","year":"1968","journal-title":"Journal of the Reticuloendothial Society"},{"key":"S0031182000060108_ref034","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1986.35.332"},{"key":"S0031182000060108_ref033","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.4049\/jimmunol.136.7.2644","article-title":"Passive transfer with serum and IgG antibodies of irradiated cercariae-induced resistance against Schistosoma mansoni in mice","volume":"136","author":"Mangold","year":"1986","journal-title":"Journal of Immunology"},{"key":"S0031182000060108_ref032","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1983.32.785"},{"key":"S0031182000060108_ref029","first-page":"233","volume-title":"The Biology of Schistosomes","author":"McLaren","year":"1987"},{"key":"S0031182000060108_ref028","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1985.tb00477.x"},{"key":"S0031182000060108_ref027","first-page":"57","article-title":"Role of granulocytes in immune defense against parasites","volume":"12","author":"McLaren","year":"1982","journal-title":"Zentralblatt f\u00fcr Bakteriologie und Parasitenkunde"},{"key":"S0031182000060108_ref024","first-page":"479","article-title":"Eosinophil-enriched inflammatory response to schistosomula in the skin of mice immune to Schistosoma mansoni","volume":"84","author":"Lichtenberg","year":"1976","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"S0031182000060108_ref023","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4049\/jimmunol.115.1.41","article-title":"Effect of intravenous silica on immune and non-immune function of the murine host","volume":"115","author":"Levy","year":"1975","journal-title":"Journal of Immunology"},{"key":"S0031182000060108_ref020","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1987.tb00527.x"},{"key":"S0031182000060108_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(82)90008-9"},{"key":"S0031182000060108_ref010","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1984.33.89"},{"key":"S0031182000060108_ref013","first-page":"144","article-title":"Suppression of contact hypersensitivity by short-term ultraviolet irradiation. I. Immunosuppression by serum from irradiated mice","volume":"71","author":"Harriott-Smith","year":"1988","journal-title":"Clinical and Experimental Immunology"},{"key":"S0031182000060108_ref012","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200005397X"},{"key":"S0031182000060108_ref009","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1981.30.806"},{"key":"S0031182000060108_ref007","first-page":"52","article-title":"Peripheral blood leukocyte count as an index of defense status in the leukopenic host","volume":"112","author":"Cawley","year":"1988","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"S0031182000060108_ref002","first-page":"395","volume-title":"In Vitro Methods in Cell-Mediated and Tumor Immunity","author":"Allison","year":"1976"},{"key":"S0031182000060108_ref042","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197203000-00026"},{"key":"S0031182000060108_ref026","volume-title":"Tropical Medicine Research Studies","volume":"1","author":"McLaren","year":"1980"},{"key":"S0031182000060108_ref011","article-title":"Contribution of IgG1 and radio-resistant cells to immune expression in guinea-pigs vaccinated with radiation-attenuated cercariae of Schistoma mansoni","author":"Delgado","year":"1989","journal-title":"International Journal for Parasitology"},{"key":"S0031182000060108_ref022","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700560319"},{"key":"S0031182000060108_ref019","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1983.tb00773.x"},{"key":"S0031182000060108_ref005","first-page":"144","article-title":"Cell-mediated damage to helminths","volume":"23","author":"Butterworth","year":"1984","journal-title":"Advances in Parasitology"},{"key":"S0031182000060108_ref037","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1978.27.76"},{"key":"S0031182000060108_ref008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1986.tb01038.x"},{"key":"S0031182000060108_ref036","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1981.tb00382.x"},{"key":"S0031182000060108_ref035","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000052446"},{"key":"S0031182000060108_ref044","first-page":"527","volume-title":"Immunology of Parasitic Infections","author":"Smithers","year":"1982"},{"key":"S0031182000060108_ref021","doi-asserted-by":"publisher","DOI":"10.1084\/jem.138.3.625"},{"key":"S0031182000060108_ref017","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.4049\/jimmunol.133.3.1587","article-title":"Defective vaccine-induced immunity to Schistosoma mansoni in P strain mice. II. Analysis of cellular responses","volume":"133","author":"James","year":"1984","journal-title":"Journal of Immunology"},{"key":"S0031182000060108_ref039","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1128\/IAI.25.2.513-520.1979","article-title":"Effect of silica on the innate resistance of inbred mice to Salmonella typhimurium infection","volume":"25","author":"O'Brien","year":"1979","journal-title":"Infection and Immunity"},{"key":"S0031182000060108_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(84)90077-8"},{"key":"S0031182000060108_ref049","first-page":"115","volume-title":"The Biology of Schistosomes","author":"Wilson","year":"1987"},{"key":"S0031182000060108_ref001","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1987.37.570"},{"key":"S0031182000060108_ref046","first-page":"389","article-title":"The effects of gamma-irradiation on haemopoiesis and red blood cell destruction in hamsters infected with Leptospira interrogans serovar ballum","volume":"68","author":"Thompson","year":"1987","journal-title":"British Journal of Experimental Pathology"},{"key":"S0031182000060108_ref015","doi-asserted-by":"publisher","DOI":"10.1084\/jem.153.3.557"},{"key":"S0031182000060108_ref004","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000053300"},{"key":"S0031182000060108_ref043","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.4049\/jimmunol.128.4.1880","article-title":"Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae. II. Analysis of immunity in hosts deficient in T lymphocytes, B lymphocytes or complement","volume":"128","author":"Sher","year":"1982","journal-title":"Journal of Immunology"},{"key":"S0031182000060108_ref006","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1982.tb00373.x"},{"key":"S0031182000060108_ref003","first-page":"465","article-title":"Potentiation by silica of growth of Mycobacterium tuberculosis in macrophage cultures","volume":"49","author":"Allison","year":"1968","journal-title":"British Journal of Experimental Pathology"},{"key":"S0031182000060108_ref014","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000051696"},{"key":"S0031182000060108_ref030","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000058492"},{"key":"S0031182000060108_ref041","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1128\/IAI.56.9.2507-2511.1988","article-title":"Effect of intravenous silica on the course of Nocardia asteroides pneumonia","volume":"56","author":"Pomeroy","year":"1988","journal-title":"Infection and Immunity"},{"key":"S0031182000060108_ref050","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000063484"},{"key":"S0031182000060108_ref025","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.4049\/jimmunol.128.4.1917","article-title":"Immunological regulation of experimental cutaneous leishmaniasis. V. Characterisation of effector and specific suppressor T cells","volume":"128","author":"Liew","year":"1982","journal-title":"Journal of Immunology"},{"key":"S0031182000060108_ref038","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/104.1.20"},{"key":"S0031182000060108_ref031","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1987.tb00537.x"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000060108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T14:31:57Z","timestamp":1685025117000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000060108\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,2]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,2]]}},"alternative-id":["S0031182000060108"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000060108","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,2]]}}}