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The isotypic pattern of this expansion, assessed by the Protein-A plaque-forming cell method, was compared with and found to differ from those occurring after infection by<jats:italic>Trypanosoma cruzi<\/jats:italic>or injection of bacterial LPS. In the infection of<jats:italic>S. mansoni<\/jats:italic>an early expansion of most immunoglobulin isotypes occurs together with a late, sustained expansion of IgG1-secreting cells. 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