{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T09:42:59Z","timestamp":1710409379331},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":6639,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1991,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>A new model for the study of granuloma formation in the liver is described. Rats received an injection of 20 000<jats:italic>Schistosoma mansoni<\/jats:italic>eggs in the portal vein and granuloma formation was evaluated at 3, 5 and 7 weeks post-injection. Liver collagen was estimated at the same time and serum procollagen III peptide, a marker of collagenesis, weekly. With this model, wherein the number of<jats:italic>S. mansoni<\/jats:italic>eggs and the time of injury are standardized, the effect of high levels of acute phase proteins especially \u03b1<jats:sub>2<\/jats:sub>-macroglobulin on granuloma formation was studied. It appeared that in rats with high levels of \u03b1<jats:sub>2<\/jats:sub>-macroglobulin the mean size of granulomas was significantly greater at 3 and 5 weeks compared with controls. In both groups an increase in liver collagen was observed during this period, reaching a peak at 5 weeks in the acute phase group. This model facilitates the study of the effects of<jats:italic>S. mansoni<\/jats:italic>eggs on granuloma formation.<\/jats:p>","DOI":"10.1017\/s0031182000060339","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:34:52Z","timestamp":1244212492000},"page":"49-56","source":"Crossref","is-referenced-by-count":1,"title":["Effect of acute phase proteins, especially \u03b1<sub>2<\/sub>-macroglobulin, on granuloma formation around<i>Schistosoma mansoni<\/i>eggs in the rat"],"prefix":"10.1017","volume":"102","author":[{"given":"J.","family":"Van Gool","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Van Tiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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