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The migration kinetics of L-[<jats:sup>75<\/jats:sup>Se]selenomethionine-labelled infective cercariae were investigated by compressed tissue autoradiography. Similar levels of skin penetration were achieved by cercariae in control and drug-treated individuals. CsA arrested 87\u201394% of the worms in the skin and ultimately all of these died in this site. Few worms (7\u201314%) migrated from the skin to the lungs and none completed migration to the liver. Nevertheless, the autoradiograms revealed a limited degree of lateral cutaneous migration by the worms present in the skins of CsA-treated mice. Results of perfusion recovery experiments carried out during the course of infection reinforced the tracking data.<\/jats:p>","DOI":"10.1017\/s0031182000060340","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:34:52Z","timestamp":1244212492000},"page":"57-63","source":"Crossref","is-referenced-by-count":13,"title":["The larvicidal activity of cyclosporin A against<i>Schistosoma mansoni<\/i>in mice"],"prefix":"10.1017","volume":"102","author":[{"given":"G. H.","family":"Munro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. R.","family":"Brannan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. H.","family":"Chappell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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