{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T15:24:30Z","timestamp":1698506670368},"reference-count":14,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":6639,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1991,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>This study was designed to test the accessory function of macrophages after activation with products of <jats:italic>Taenia multiceps<\/jats:italic> coenuri. Activation was carried out by intraperitoneal injection of mice with coenurus fluid or protoscolex culture supernatant, and function was assessed by adding these macrophages in progressively increasing numbers to macrophage-depleted lymphocyte cultures transforming under the influence of plant mitogens or coenurus-fluid mitogen. In contrast to normal macrophages, which have a progressively enhancing action on the above reactions, parasite-activated macro-phages at similar concentrations were progressively inhibitory. However, low concentrations of the activated macrophages enhanced mitosis as well as, or better than, normal. Lymph node cells from injected mice showed abnormal response to macrophage-derived signals. In particular there was subnormal reaction to macrophages in the presence of coenurus mitogen. These results suggest that <jats:italic>T. multiceps<\/jats:italic> coenuri may survive in the host because of their ability to reduce effective interaction between lymphocytes and accessory cells.<\/jats:p>","DOI":"10.1017\/s0031182000060443","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:34:52Z","timestamp":1244212492000},"page":"133-140","source":"Crossref","is-referenced-by-count":10,"title":["Lymphoreticular responses to metacestodes: <i>Taenia multiceps<\/i> (Cestoda) can modify interaction between accessory cells and responder cells during lymphocyte activation"],"prefix":"10.1017","volume":"102","author":[{"given":"N. K.","family":"Rakha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. B.","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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