{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T05:02:18Z","timestamp":1750482138689},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":6701,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1990,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>This paper examines the effects of host age and sex on the frequency distribution of <jats:italic>Wuchereria bancrofti<\/jats:italic> infections in the human host. Microfilarial counts from a large data base on the epidemiology of bancroftian filariasis in Pondicherry, South India are analysed. Frequency distributions of microfilarial counts divided by age are successfully described by zero-truncated negative binomial distributions, fitted by maximum likelihood. Parameter estimates from the fits indicate a significant trend of decreasing overdispersion with age in the distributions above age 10; this pattern provides indirect evidence for the operation of density-dependent constraints on microfilarial intensity. The analysis also provides estimates of the proportion of mf-positive individuals who are identified as negative due to sampling errors (around 5% of the total negatives). This allows the construction of corrected mf age\u2013prevalence curves, which indicate that the observed prevalence may underestimate the true figures by between 25% and 100%. The age distribution of mf-negative individuals in the population is discussed in terms of current hypotheses about the interaction between disease and infection.<\/jats:p>","DOI":"10.1017\/s0031182000060625","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:36:07Z","timestamp":1244212567000},"page":"429-434","source":"Crossref","is-referenced-by-count":24,"title":["Frequency distribution of <i>Wuchereria bancrofti<\/i> microfilariae in human populations and its relationships with age and sex"],"prefix":"10.1017","volume":"101","author":[{"given":"P. K.","family":"Das","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Manoharan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Srividya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. T.","family":"Grenfell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A. P.","family":"Bundy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Vanamail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000060625_ref016","volume-title":"Human Filariasis: a Global Survey of Epidemiology and Control","author":"Sasa","year":"1976"},{"key":"S0031182000060625_ref014","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000058261"},{"key":"S0031182000060625_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(84)90309-2"},{"key":"S0031182000060625_ref010","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000060613"},{"key":"S0031182000060625_ref009","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-68635-1_6"},{"key":"S0031182000060625_ref008","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-2901-3_7"},{"key":"S0031182000060625_ref011","first-page":"29","article-title":"Analysis of the W. bancrofti population in people of Western Samoa","volume":"38","author":"Hairston","year":"1968","journal-title":"WHO Bulletin"},{"key":"S0031182000060625_ref007","doi-asserted-by":"publisher","DOI":"10.1038\/315491a0"},{"key":"S0031182000060625_ref005","volume-title":"GLIM Version 3.77 User Manual","author":"Baker","year":"1978"},{"key":"S0031182000060625_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60561-8"},{"key":"S0031182000060625_ref003","doi-asserted-by":"publisher","DOI":"10.1038\/315493a0"},{"key":"S0031182000060625_ref002","doi-asserted-by":"publisher","DOI":"10.1038\/297557a0"},{"key":"S0031182000060625_ref013","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000081762"},{"key":"S0031182000060625_ref001","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000047739"},{"key":"S0031182000060625_ref018","article-title":"Age-specific acquisition and loss of Wuchereria bancrofti infection in humans and estimation of the period of microfilarial production","author":"Vanamail","year":"1990","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"S0031182000060625_ref006","first-page":"214","article-title":"The population ecology of human helminth infections","volume":"104","author":"Bunday","year":"1988","journal-title":"Philosophical Transactions of the Royal Society of London"},{"key":"S0031182000060625_ref017","first-page":"177","article-title":"Problems of clinical and biological measurements in the epidemiology and control of filarial infections","volume":"68","author":"Southgate","year":"1974","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"S0031182000060625_ref015","volume-title":"The Pondicherry Project on Integrated Disease Vector Control","author":"Rajagopalan","year":"1987"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000060625","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T19:38:09Z","timestamp":1558208289000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000060625\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,12]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,12]]}},"alternative-id":["S0031182000060625"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000060625","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,12]]}}}