{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:17:44Z","timestamp":1761488264132},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":6701,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1990,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Jirds (<jats:italic>Meriones libycus<\/jats:italic>) were infected with various numbers of<jats:italic>Acanthocheilonema viteae<\/jats:italic>L3 stage parasites. During the course of the ensuing 16 weeks, blood samples were collected at 2 weekly intervals and the amount of the major parasite excretory\u2013secretory product (E\u2013S 62) and antibodies directed against it measured. After 16 weeks, animals were sacrificed and the size of the mature worm burden established. In spite of interaction between E\u2013S 62 and host antibody, a statistically significant relationship was found to exist between the amount of E\u2013S 62 present in the bloodstream and the size of the parasite load. It is suggested that the detectable antigen level is more influenced by the size of the worm burden than the presence of antibody and that antibody is only likely to affect adversely antigen measurement in situations where the amount released is relatively low. Examples of this are early in infection and in low-level infections. These ideas are discussed in relation to the development and assessment of serological assays which attempt to predict parasite burden in human filarial infections.<\/jats:p>","DOI":"10.1017\/s0031182000060637","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:36:07Z","timestamp":1244212567000},"page":"435-444","source":"Crossref","is-referenced-by-count":15,"title":["Association between circulating antigen and parasite load in a model filarial system,<i>Acanthocheilonema viteae<\/i>in jirds"],"prefix":"10.1017","volume":"101","author":[{"given":"W.","family":"Harnett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Worms","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Grainger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. D. 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