{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T22:41:10Z","timestamp":1698532870771},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":6701,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1990,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Cyclosporin A (CsA), administered in 5 daily subcutaneous doses of 50 mg\/kg to MF1 mice immediately following infection with<jats:italic>Hymenolepis diminuta<\/jats:italic>enhanced parasite growth relative to controls. Drug administered at 24 h intervals for 10 days, and thereafter every 48 h to MF1 and CBA\/Ca mice infected with<jats:italic>H. diminuta<\/jats:italic>, increased worm survival and growth, delayed host-mediated expulsion of the parasite and enabled some worms to develop to patency. Worm survival and weight both increased in a dose-dependent manner following daily CsA treatment of infected CBA\/Ca and BALB\/c mice (0\u2013150 mg\/kg CsA\/day). Delay in parasite elimination was accompanied by increased frequency of worm-attachment in the anterior small intestine (MF1 mice given 5 daily doses of CsA [0\u2013150 mg\/kg] following infection); posteriad migration of worms was restricted in a dose-dependent manner. The data presented contrast markedly with the action of the same drug on<jats:italic>H. microstoma<\/jats:italic>in mice. Thus CsA treatment acts in opposing ways on two closely related parasites in the same host; this possibly reflects the mechanistic antagonism between immunosuppression and anthelmintic activity. This paper reports the first use of a specific T cell-suppressive drug on<jats:italic>H. diminuta<\/jats:italic>in the mouse, implicating the role of T cells in protective immunity to this parasite.<\/jats:p>","DOI":"10.1017\/s0031182000060674","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:36:07Z","timestamp":1244212567000},"page":"465-472","source":"Crossref","is-referenced-by-count":11,"title":["Action of cyclosporin A on the tapeworm<i>Hymenolepis diminuta<\/i>in mice"],"prefix":"10.1017","volume":"101","author":[{"given":"J. M.","family":"Wastling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Gerrard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. H.","family":"Chappell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000060674_ref020","first-page":"50","volume-title":"Cyclosporin, Mode of Action and Clinical Applications","author":"Thomson","year":"1989"},{"key":"S0031182000060674_ref019","first-page":"45","volume-title":"Cyclosporin A, Proceedings of an International Conference on Cyclosporin A","author":"Ryffel","year":"1982"},{"key":"S0031182000060674_ref015","first-page":"4","article-title":"Exacerbation of Trypanosoma cruzi infection in mice treated with the immunoregulatory agent cyclosporin A","volume":"34","author":"Kierszenbaum","year":"1983","journal-title":"Tropenmedizin und Parasitologie"},{"key":"S0031182000060674_ref014","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1128\/IAI.12.6.1478-1479.1975","article-title":"Thymus dependence of tapeworm (Hymenolepis diminuta) elimination from mice","volume":"12","author":"Issak","year":"1975","journal-title":"Infection and Immunity"},{"key":"S0031182000060674_ref013","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/145.2.767"},{"key":"S0031182000060674_ref011","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000045479"},{"key":"S0031182000060674_ref009","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00011615"},{"key":"S0031182000060674_ref008","first-page":"317","article-title":"Experimental infections of rats and mice with Hymenolepis diminuta (Cestoda, Hymenolepididae), and influence of immunosuppression on the infection in mice","volume":"28","author":"Choromanski","year":"1983","journal-title":"Acta Parasitologica Polonica"},{"key":"S0031182000060674_ref006","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.10.1567"},{"key":"S0031182000060674_ref005","first-page":"291","article-title":"Studies on the action of Cyclosporin A against Schistosoma mansoni and other parasitic infections","volume":"20","author":"Chappell","year":"1988","journal-title":"Transplantation Proceedings"},{"key":"S0031182000060674_ref004","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1988.tb00207.x"},{"key":"S0031182000060674_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000043225"},{"key":"S0031182000060674_ref002","first-page":"35","volume-title":"Cyclosporin A, Proceedings of an International Conference on Cyclosporin A","author":"Beveridge","year":"1982"},{"key":"S0031182000060674_ref016","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1985.34.861"},{"key":"S0031182000060674_ref017","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1128\/IAI.56.1.7-12.1988","article-title":"Cyclosporin A inhibits the growth of Cryptococcus neoformans in a murine model","volume":"56","author":"Mody","year":"1988","journal-title":"Infection and Immunity"},{"key":"S0031182000060674_ref018","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000060078"},{"key":"S0031182000060674_ref012","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000044279"},{"key":"S0031182000060674_ref021","first-page":"599","article-title":"Suppression of delayed-type hypersensitivity reactions and lymphokine production by cyclosporin A in the mouse","volume":"52","author":"Thomson","year":"1983","journal-title":"Clinical and Experimental Immunology"},{"key":"S0031182000060674_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000062211"},{"key":"S0031182000060674_ref001","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1986.35.496"},{"key":"S0031182000060674_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-058980-7.50015-4"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000060674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T06:48:44Z","timestamp":1589870924000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000060674\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,12]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,12]]}},"alternative-id":["S0031182000060674"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000060674","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,12]]}}}