{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:47:55Z","timestamp":1761155275333},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":6274,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The serum antibody responses of 124 people naturally exposed to <jats:italic>Ascaris lumbricoides<\/jats:italic> infection were analysed by immunoprecipitation of radio-isotope labelled 3rd- and 4th-stage larval <jats:italic>Ascaris suum<\/jats:italic> excretory and secretory antigens (L3\/4 ES). Profiles of antigens recognized were visualized by polyacrylamide gel electrophoresis (SDS\u2013PAGE), and the band intensities of the 12 major precipitated antigens were individually scored. Most subjects were seropositive, but considerable variation was observed in the amount of total and individual ES antigens precipitated. The sex- and age-related profiles of antibody levels followed similar patterns to those of egg output. In addition, total antibody scores of individuals were closely correlated (<jats:italic>r<\/jats:italic> = 0.47\u20130.52) with their eggs per gram of faeces (e.p.g.) collected 4 months <jats:italic>after<\/jats:italic> blood samples were taken. These findings suggest that antibody levels against larval ES antigens reflect recent exposure and are consistent with the hypothesis that establishment of adult worms is proportional to the number of larvae that recently migrated through the lung.<\/jats:p>","DOI":"10.1017\/s0031182000060893","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T10:26:48Z","timestamp":1244197608000},"page":"153-159","source":"Crossref","is-referenced-by-count":22,"title":["Immunoepidemiology of <i>Ascaris lumbricoides<\/i>: relationships between antibody specificities, exposure and infection in a human community"],"prefix":"10.1017","volume":"104","author":[{"given":"M. R.","family":"Haswell-Elkins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. W.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. B.","family":"Elkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. M.","family":"Maizels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000060893_ref011","first-page":"20","article-title":"Homology and heterology between the secreted antigens of the parasitic larval stages of Ascaris lumbricoides and Ascaris suum","volume":"61","author":"Kennedy","year":"1987","journal-title":"Clinical and Experimental Immunology"},{"key":"S0031182000060893_ref009","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200005976X"},{"key":"S0031182000060893_ref008","doi-asserted-by":"publisher","DOI":"10.1038\/349243a0"},{"key":"S0031182000060893_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(88)90448-8"},{"key":"S0031182000060893_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000081749"},{"key":"S0031182000060893_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(86)90384-6"},{"key":"S0031182000060893_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(88)90077-4"},{"key":"S0031182000060893_ref010","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1989.tb00925.x"},{"key":"S0031182000060893_ref013","volume-title":"Biometry","author":"Sokal","year":"1981"},{"key":"S0031182000060893_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(87)90273-2"},{"key":"S0031182000060893_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(87)90091-3"},{"key":"S0031182000060893_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(86)90367-6"},{"key":"S0031182000060893_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(88)90076-2"},{"key":"S0031182000060893_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(85)90028-1"},{"key":"S0031182000060893_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(84)90071-3"},{"key":"S0031182000060893_ref012","doi-asserted-by":"publisher","DOI":"10.1021\/bi00615a031"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000060893","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T18:37:00Z","timestamp":1558031820000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000060893\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,2]]}},"alternative-id":["S0031182000060893"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000060893","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,2]]}}}