{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:55:57Z","timestamp":1785527757135,"version":"3.56.0"},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":7188,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1989,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>A comparison was made of the development, survival and reproduction of 5 isolates of <jats:italic>Trichinella spiralis<\/jats:italic> in inbred mice. Low responder C57BL\/10 mice allowed worms of all isolates to survive longer and reproduce more successfully than did high responder NIH mice, suggesting that host immunity exerted a dominant influence upon infectivity. One isolate (Is-5 (W) \u2014 an arctic isolate) had a markedly lower infectivity than all other isolates, and was selected for more detailed study, together with isolate Is-1 (S) (a temperate isolate) which showed high infectivity. The lower infectivity of Is-5 (W) reflected a more rapid onset of immunity in mice infected with this parasite, immunity reducing the reproductive potential of female worms and causing an early expulsion from the intestine. No evidence of a dose-dependent suppression of immunity was found to explain the higher infectivity of Is-1 (S). Is-5 (W) provided a very rapid mucosal mastocytosis in infected mice, whereas Is-1 (S) caused no measurable response. In contrast, Is-1 (S) elicited higher levels of circulating parasite-specific antibodies than did Is-5 (W). These results are discussed in relation to the interplay of parasite immunogenicity and host immune responsiveness in determining infectivity, and point to the importance of identifying those immunodominant parasite molecules which control the balance of the host\u2014parasite relationship.<\/jats:p>","DOI":"10.1017\/s0031182000061059","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T10:50:07Z","timestamp":1244199007000},"page":"83-88","source":"Crossref","is-referenced-by-count":28,"title":["Infectivity of <i>Trichinella<\/i> isolates in mice is determined by host immune responsiveness"],"prefix":"10.1017","volume":"99","author":[{"given":"F.","family":"Bolas-Fernandez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Wakelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000061059_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(79)90128-0"},{"key":"S0031182000061059_ref011","first-page":"203","article-title":"Genetic control of immunity to Trichinella spiralis in mice: capacity of cells from slow responder mice to transfer immunity to syngeneic and F1 hybrid recipients","volume":"86","author":"Wakelin","year":"1985","journal-title":"Immunology"},{"key":"S0031182000061059_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(66)90270-7"},{"key":"S0031182000061059_ref009","first-page":"39","volume-title":"Ecology and Genetics of Host\u2014Parasite Interactions","author":"Wakelin","year":"1985"},{"key":"S0031182000061059_ref005","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000044929"},{"key":"S0031182000061059_ref014","first-page":"811","article-title":"H-2-controlled, dose-dependent suppression of the response that expels adult Trichinella spiralis from the small intestine of mice","volume":"53","author":"Wassom","year":"1984","journal-title":"Immunology"},{"key":"S0031182000061059_ref013","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000047843"},{"key":"S0031182000061059_ref008","first-page":"375","article-title":"Genetic variation in immunity to Trichinella spiralis in the mouse","volume":"29","author":"Wakelin","year":"1983","journal-title":"Wiadomosci Parazytologiczne"},{"key":"S0031182000061059_ref015","doi-asserted-by":"publisher","DOI":"10.2307\/3282457"},{"key":"S0031182000061059_ref003","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-3578-8_2"},{"key":"S0031182000061059_ref007","doi-asserted-by":"publisher","DOI":"10.1139\/z80-172"},{"key":"S0031182000061059_ref004","doi-asserted-by":"publisher","DOI":"10.2307\/3281845"},{"key":"S0031182000061059_ref010","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-3578-8_8"},{"key":"S0031182000061059_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(82)90097-2"},{"key":"S0031182000061059_ref012","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000048472"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000061059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T15:56:30Z","timestamp":1558281390000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000061059\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,8]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,8]]}},"alternative-id":["S0031182000061059"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000061059","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,8]]}}}