{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:13:15Z","timestamp":1772896395370,"version":"3.50.1"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":6214,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1992,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The role of pulmonary cellular responses in the induction and expression of immunity to<jats:italic>Schistosoma mansoni<\/jats:italic>has been evaluated. From experiments in which mice were challenged at intervals after vaccination, we conclude that the resistance mechanism operating in the lungs develops between days 11 and 20. Injection of<jats:sup>51<\/jats:sup>Cr-labelled splenocytes revealed that mononuclear cell recruitment to the lungs, stimulated by the arrival of attenuated schistosomula, intensified progressively between days 10 and 16 post-vaccination. The increased cellularity was reflected in a 19\u00b75% augmentation in the wet-weight index (WW). The period of enhanced cell recruitment therefore coincided with the build-up of resistance. By day 22 post-vaccination infiltration had declined, whilst WW remained elevated. This indicates the persistence of recruited cells, which include schistosome-reactive T lymphocytes, in the lungs. We were unable to demonstrate augmented recruitment of<jats:sup>51<\/jats:sup>Cr-labelled cells after challenge of vaccinated mice, but WW rose slightly, peaking on day 12. Although clearly of a lower order than the primary response, the secondary response was more rapid, implying the existence of immunological memory. These results accord with the concept that schistosome-reactive T lymphocytes recruited after vaccination \u2018arm\u2019 the lungs against the arrival of challenge parasites.<\/jats:p>","DOI":"10.1017\/s0031182000061746","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:25:25Z","timestamp":1244211925000},"page":"299-307","source":"Crossref","is-referenced-by-count":8,"title":["The role of mononuclear-cell recruitment to the lungs in the development and expression of immunity to<i>Schistosoma mansoni<\/i>"],"prefix":"10.1017","volume":"104","author":[{"given":"E. C.","family":"Ratcliffe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000061746_ref012","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1017\/S0031182000054512","article-title":"The migration and survival of gamma-irradiated Schistosoma mansoni larvae, and the duration of host-parasite contact in relation to the induction of resistance in mice","volume":"88","author":"Mangold","year":"1984","journal-title":"Parasitology"},{"key":"S0031182000061746_ref022","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1985.34.96"},{"key":"S0031182000061746_ref009","first-page":"3957","article-title":"Defective vaccine induced immunity to Schistosoma mansoni in P strain mice. III. 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II. Analysis of cellular responses","volume":"133","author":"James","year":"1984","journal-title":"Journal of Immunology"},{"key":"S0031182000061746_ref002","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.4049\/jimmunol.140.10.3573","article-title":"Pulmonary leucocytic responses in vaccinated mice are linked to acquired immunity against Schistosoma mansoni","volume":"140","author":"Aitken","year":"1988","journal-title":"Journal of Immunology"},{"key":"S0031182000061746_ref007","volume-title":"Practical Immunology","author":"Hudson","year":"1989"},{"key":"S0031182000061746_ref017","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000059679"},{"key":"S0031182000061746_ref011","first-page":"135","article-title":"Lymphocyte subsets involved in delayed-type hypersensitivity","volume":"7","author":"Liew","year":"1984","journal-title":"Advances in Inflammation Research"},{"key":"S0031182000061746_ref010","doi-asserted-by":"publisher","DOI":"10.2307\/3282668"},{"key":"S0031182000061746_ref023","first-page":"115","volume-title":"The Biology of Schistosomes","author":"Wilson","year":"1987"},{"key":"S0031182000061746_ref015","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000052446"},{"key":"S0031182000061746_ref018","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.4049\/jimmunol.143.7.2342","article-title":"Lung-phase immunity to Schistosoma mansoni: flow cytometric analysis of macrophage activation states in vaccinated mice","volume":"143","author":"Menson","year":"1989","journal-title":"Journal of Immunology"},{"key":"S0031182000061746_ref020","doi-asserted-by":"crossref","first-page":"159","DOI":"10.4049\/jimmunol.118.1.159","article-title":"The effect of locally injected vasoactive amines on the elicitation of delayed-type hypersensitivity","volume":"118","author":"Schwartz","year":"1977","journal-title":"Journal of Immunology"},{"key":"S0031182000061746_ref026","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1128\/IAI.31.2.712-715.1981","article-title":"Use of 51Cr-labelled mononuclear cells for measuring the cellular immune response in mouse lungs","volume":"31","author":"Zarkower","year":"1981","journal-title":"Infection and Immunity"},{"key":"S0031182000061746_ref001","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1987.37.570"},{"key":"S0031182000061746_ref016","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000056547"},{"key":"S0031182000061746_ref004","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1988.38.529"},{"key":"S0031182000061746_ref014","first-page":"273","article-title":"High radiosensitivity of induction in contrast to radioresistance of expression of cells mediating delayed-type hypersensitivity during response to sheep red blood cells in mice","volume":"37","author":"Marchal","year":"1979","journal-title":"Immunology"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000061746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T09:01:38Z","timestamp":1710406898000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000061746\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,4]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,4]]}},"alternative-id":["S0031182000061746"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000061746","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,4]]}}}