{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:10:01Z","timestamp":1739146201390,"version":"3.37.0"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":7310,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1989,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The<jats:italic>in vivo<\/jats:italic>activity of two cyclosporins, cyclosporin A (CsA) and a non-immunosuppressive derivative of dihydrocylosporin A (DHCsA-d) against three tapeworms,<jats:italic>Hymenolepis microstoma, H. diminuta<\/jats:italic>and<jats:italic>Mesocestoides corti<\/jats:italic>, has been assessed. CsA reversibly reduced the dry weight of<jats:italic>H. microstoma<\/jats:italic>in the mouse, briefly delayed oviposition and had a statistically significant effect on worm numbers recovered. Oral and subcutaneous treatments of both CsA and DHCsA-d were effective in reducing worm weight; juvenile worms were most susceptible but worms of all ages responded to drug by a dramatic reduction in weight from which they recovered. Multiple courses of CsA were no more active than single courses of treatment but dose response suggested that a threshold level of drug was necessary to evoke activity. By contrast,<jats:italic>H. diminuta<\/jats:italic>in the rat was completely unaffected by CsA but no explanation for the differences in drug response by these two closely related helminths is forthcoming.<jats:italic>Mesocestoides corti<\/jats:italic>responded reversibly to CsA in the mouse by a reduction in asexual proliferation of both liver and peritoneal cavity tetrathyridia. The data presented argue in favour of a range of anti-parasitic activities by cyclosporins but the details of the various putative modes of action remain to be defined.<\/jats:p>","DOI":"10.1017\/s0031182000062211","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T16:04:35Z","timestamp":1244217875000},"page":"291-299","source":"Crossref","is-referenced-by-count":15,"title":["Action of cyclosporin A on the tapeworms<i>Hymenolepis microstoma, H. diminuta<\/i>and<i>Mesocestoides corti in vivo<\/i>"],"prefix":"10.1017","volume":"98","author":[{"given":"L. H.","family":"Chappell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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