{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:25:07Z","timestamp":1758633907445},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":11510,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1977,10]]},"abstract":"<jats:p><jats:italic>Hymenolepis microstoma<\/jats:italic> from secondary infections in mice were found to grow initially more slowly than <jats:italic>H. microstoma<\/jats:italic> from primary infections. Eventually a similar rate of growth was attained by both kinds of worm. After transplantation, young worms (\u22644 days old) grew more slowly in previously infected than in naive mice. In contrast, 10-day-old worms grew equally well in naive or resistant mice. The administration of cortisone to mice during a secondary infection of <jats:italic>H. microstoma<\/jats:italic> inhibited the stunting of growth in young worms which were able to grow as well as those in a primary infection. The effects of the cortisone persisted for less than 4 days. Worms in a secondary infection given 4days after cortisone treatment were stunted in growth. These experiments suggest that the susceptibility of the worms to the resistance of the mouse applies to the first 4 days within the host. The loss or reduction of this susceptibility might be associated with the worms' entry into the bile duct which occurs 3\u20134 days after infection.<\/jats:p>","DOI":"10.1017\/s0031182000062387","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T16:54:22Z","timestamp":1244220862000},"page":"241-249","source":"Crossref","is-referenced-by-count":9,"title":["<i>Hymenolepis microstoma<\/i>: a change in susceptibility to resistance with increasing age of the parasite"],"prefix":"10.1017","volume":"75","author":[{"given":"R. J.","family":"Howard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000062387_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(67)90033-1"},{"key":"S0031182000062387_ref012","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000071511"},{"key":"S0031182000062387_ref010","doi-asserted-by":"publisher","DOI":"10.1007\/BF00329011"},{"key":"S0031182000062387_ref009","unstructured":"Howard R. J. (1976 b). Aspects of the host\/parasite relationship of Hymenolepis microstoma. Ph.D. thesis, University of Glasgow."},{"key":"S0031182000062387_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000051349"},{"key":"S0031182000062387_ref005","doi-asserted-by":"publisher","DOI":"10.2307\/3278412"},{"key":"S0031182000062387_ref003","unstructured":"Goodall R. I. (1973). Studies on the growth, location specificity and immunobiology, of some hymenolepid tapeworms. Ph.D. thesis, University of Glasgow."},{"key":"S0031182000062387_ref001","first-page":"120","article-title":"Longevity of the liver fluke, Fasciola sp. in sheep","volume":"19","author":"Durbin","year":"1952","journal-title":"Proceedings of the Helminthological Society of Washington"},{"key":"S0031182000062387_ref013","first-page":"313","volume-title":"Statistics with Applications to the Biological and Health Sciences","author":"Remmington","year":"1970"},{"key":"S0031182000062387_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000046187"},{"key":"S0031182000062387_ref014","doi-asserted-by":"publisher","DOI":"10.2307\/3277014"},{"key":"S0031182000062387_ref002","first-page":"160","article-title":"Antibodies in mice infected with Hymenolepis microstoma against freshly excysted cysticercoids as demonstrated by the fluorescent antibody technique","volume":"51","author":"Foster","year":"1965","journal-title":"Journal of Parasitology"},{"key":"S0031182000062387_ref011","first-page":"157","volume-title":"Essays on Growth and Form","author":"Medawar","year":"1945"},{"key":"S0031182000062387_ref008","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000049519"},{"key":"S0031182000062387_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1935(17)36460-6"},{"key":"S0031182000062387_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(68)90100-8"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000062387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T21:07:41Z","timestamp":1558991261000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000062387\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,10]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1977,10]]}},"alternative-id":["S0031182000062387"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000062387","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,10]]}}}