{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:12:36Z","timestamp":1775304756950,"version":"3.50.1"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":6762,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1990,10]]},"abstract":"<jats:p>The genetic influences upon host variation in eosinophilia and resistance to helminth infection, and the relationship between these parameters, was investigated in 9 inbred and 3 hybrid strains of mice infected with<jats:italic>Mesocestoides corti.<\/jats:italic>Blood, bone marrow, spleen and peritoneal fluid eosinophilia were far higher in SJL mice than in any other inbred strain. SWR, NIH, C3H and BALB\/c mice were high responders to<jats:italic>M. corti<\/jats:italic>whereas CBA and 3 congenic strains sharing the B10 background (C57BL\/10, B10.S, B10.G) were low responders. Some of the genes for high eosinophil responsiveness appeared to be dominant, as F<jats:sub>1<\/jats:sub>hybrids from high and low response parental strains were intermediate to high in response to infection. SJL and NIH strains were highly susceptible to infection with<jats:italic>M. corti<\/jats:italic>, larval burdens at 21 days after infection with 100 tetrathyridia being considerably higher (&gt;1000) than all other strains. BALB\/c (\u2243 700 larvae) were designated susceptible, SWR (&gt;400 larvae) were resistant and the BIO congenics (&lt;400 larvae) were highly resistant. Genes influencing resistance also appeared to be dominant, as F<jats:sub>1<\/jats:sub>hybrids between resistant and susceptible parental strains were intermediate to resistant on infection. The overall response patterns indicate a direct correlation between susceptibility to infection and high eosinophil responsiveness, but this relationship is not consistent in all strains.<\/jats:p>","DOI":"10.1017\/s0031182000063356","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:35:23Z","timestamp":1244212523000},"page":"291-299","source":"Crossref","is-referenced-by-count":11,"title":["Genetic influences upon eosinophilia and resistance in mice infected with<i>Mesocestoides corti<\/i>"],"prefix":"10.1017","volume":"101","author":[{"given":"D. A.","family":"Lammas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. A.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Wakelin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000063356_ref015","first-page":"390","volume-title":"Tropical and Geographical Medicine","author":"Ottesen","year":"1985"},{"key":"S0031182000063356_ref014","first-page":"323","volume-title":"Lymphokines and Interferons a Practical Approach","author":"O'garra","year":"1987"},{"key":"S0031182000063356_ref021","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1984.tb00812.x"},{"key":"S0031182000063356_ref017","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.1.61"},{"key":"S0031182000063356_ref001","doi-asserted-by":"publisher","DOI":"10.3109\/08820138109050700"},{"key":"S0031182000063356_ref019","volume-title":"Eosinophils.","author":"Spry","year":"1988"},{"key":"S0031182000063356_ref026","first-page":"329","article-title":"Genetic control of eosinophilia. Mouse strain variation in response to antigens of parasite origin","volume":"51","author":"Wakelin","year":"1983","journal-title":"Clinical and Experimental Immunology"},{"key":"S0031182000063356_ref004","first-page":"489","article-title":"Defective regulation of erythrocyte auto-antibodies in SJL mice","volume":"51","author":"Cooke","year":"1984","journal-title":"Immunology"},{"key":"S0031182000063356_ref003","first-page":"871","article-title":"Variations in peripheral blood eosinophil levels in normal and Schistosoma mansoni infected mice","volume":"83","author":"Colley","year":"1974","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"S0031182000063356_ref005","first-page":"21","volume-title":"Genetics of Resistance to Bacterial and Parasitic Infection","author":"Festing","year":"1988"},{"key":"S0031182000063356_ref029","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(88)90149-X"},{"key":"S0031182000063356_ref025","first-page":"153","volume-title":"Genetics of Resistance to Bacterial and Parasitic Infection","author":"Wakelin","year":"1988"},{"key":"S0031182000063356_ref007","first-page":"549","article-title":"Detection of a new type of mouse eosinophil colony by Luxol-Fast-blue staining","volume":"8","author":"Johnson","year":"1980","journal-title":"Experimental Haematology"},{"key":"S0031182000063356_ref022","doi-asserted-by":"publisher","DOI":"10.1007\/BF01567789"},{"key":"S0031182000063356_ref020","first-page":"16","article-title":"Detection of eosinophil differentiation factor and its relationship to eosinophilia in Mesocestoides corti-infected mice","volume":"14","author":"Strath","year":"1986","journal-title":"Experimental Hematology"},{"key":"S0031182000063356_ref006","first-page":"445","article-title":"Immunological defects in SJL mice","volume":"59","author":"Hutchings","year":"1986","journal-title":"Immunology"},{"key":"S0031182000063356_ref027","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(82)90091-1"},{"key":"S0031182000063356_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60287-0"},{"key":"S0031182000063356_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(88)90078-1"},{"key":"S0031182000063356_ref009","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1987.tb00532.x"},{"key":"S0031182000063356_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(78)90064-4"},{"key":"S0031182000063356_ref011","first-page":"137","article-title":"Genetic control of eosinophilia. Analysis of production and response to eosinophil differentiation factor in strains of mice infected with Trichinella spiralis","volume":"77","author":"Lammas","year":"1989","journal-title":"Clinical and Experimental Immunology"},{"key":"S0031182000063356_ref013","doi-asserted-by":"publisher","DOI":"10.2307\/3280028"},{"key":"S0031182000063356_ref023","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.4049\/jimmunol.127.5.2083","article-title":"Cyclophosphamide pretreatment induces eosinophilia to non-parasite antigens","volume":"127","author":"Vadas","year":"1981","journal-title":"Journal of Immunology"},{"key":"S0031182000063356_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(75)90043-0"},{"key":"S0031182000063356_ref018","doi-asserted-by":"publisher","DOI":"10.2307\/3276097"},{"key":"S0031182000063356_ref024","doi-asserted-by":"crossref","first-page":"691","DOI":"10.4049\/jimmunol.128.2.691","article-title":"Genetic control of eosinophilia in mice: gene(s) expressed in bone marrow-derived cells control high responsiveness","volume":"128","author":"Vadas","year":"1982","journal-title":"Journal of Immunology"},{"key":"S0031182000063356_ref008","doi-asserted-by":"publisher","DOI":"10.2307\/3278080"},{"key":"S0031182000063356_ref028","doi-asserted-by":"publisher","DOI":"10.1007\/BF00934013"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000063356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T14:31:39Z","timestamp":1685025099000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000063356\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,10]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,10]]}},"alternative-id":["S0031182000063356"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000063356","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,10]]}}}