{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:27:40Z","timestamp":1772753260664,"version":"3.50.1"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":8465,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1986,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The variable antigen repertoire expressed by metacyclic<jats:italic>Trypanosoma brucei rhodesiense<\/jats:italic>is not influenced by the anamnestic expression whereby the variable antigen type (VAT) ingested by a tsetse fly is present at high levels in early bloodstream populations of fly-infected mice. This has been demonstrated by feeding to<jats:italic>Glossina morsitans<\/jats:italic>a trypanosome line expressing a VAT which is normally a component of the metacyclic repertoire. The VAT did not constitute a significantly increased proportion of the resultant metacyclic population which would have occurred had anamnestic expression and metacyclic expression been linked. Five other metacyclic VATs were also present at control levels. We conclude that the mechanisms of expression of VATs in the fly and in the mammal are independently controlled.<\/jats:p>","DOI":"10.1017\/s0031182000063459","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T16:20:57Z","timestamp":1244218857000},"page":"67-73","source":"Crossref","is-referenced-by-count":22,"title":["Independent expression of the metacyclic and bloodstream variable antigen repertoires of<i>Trypanosoma brucei rhodesiense<\/i>"],"prefix":"10.1017","volume":"92","author":[{"given":"C. M. R.","family":"Turner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Barry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Vickerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000063459_ref013","article-title":"The molecular biology of antigenic variation in trypanosomes: Gene rearrangements and discontinuous transcription","author":"De Lange","year":"1985","journal-title":"International Review of Cytology"},{"key":"S0031182000063459_ref027","doi-asserted-by":"publisher","DOI":"10.1038\/306196a0"},{"key":"S0031182000063459_ref023","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/10.19.5905"},{"key":"S0031182000063459_ref022","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1984.0105"},{"key":"S0031182000063459_ref011","unstructured":"Crowe J. S. (1983). Antigenic variation in cyclically transmitted African trypanosomes. Ph.D. thesis, University of Glasgow."},{"key":"S0031182000063459_ref007","doi-asserted-by":"publisher","DOI":"10.1038\/307563a0"},{"key":"S0031182000063459_ref021","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(79)90062-6"},{"key":"S0031182000063459_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90146-5"},{"key":"S0031182000063459_ref002","doi-asserted-by":"publisher","DOI":"10.1038\/306699a0"},{"key":"S0031182000063459_ref019","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1002\/j.1460-2075.1983.tb01648.x","article-title":"Repression of glycoprotein synthesis and release of surface coat during transformation of Trypanosoma brucei","volume":"2","author":"Overath","year":"1983","journal-title":"The EMBO Journal"},{"key":"S0031182000063459_ref016","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000080574"},{"key":"S0031182000063459_ref001","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1960.11685955"},{"key":"S0031182000063459_ref015","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000080562"},{"key":"S0031182000063459_ref014","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/j.1460-2075.1985.tb03728.x","article-title":"Inactivation and reactivation of a variant specific antigen gene in cyclically transmitted Trypanosoma brucei","volume":"4","author":"Delauw","year":"1985","journal-title":"The EMBO Journal"},{"key":"S0031182000063459_ref018","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/j.1460-2075.1984.tb01975.x","article-title":"The inactivation and reactivation of an expression-linked gene copy for a variant surface glycoprotein in Trypanosoma brucei","volume":"3","author":"Michels","year":"1984","journal-title":"The EMBO Journal"},{"key":"S0031182000063459_ref017","first-page":"369","article-title":"First tsetse fly transmission of the \u2018AnTat\u2019 serodeme of Trypanosoma brucei","volume":"57","author":"Le Ray","year":"1977","journal-title":"Annales de la Soci\u00e9t\u00e9 belge du M\u00e9dicine tropicale"},{"key":"S0031182000063459_ref026","first-page":"204","volume-title":"Immunology of Parasitic Infections","author":"Vickerman","year":"1982"},{"key":"S0031182000063459_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(77)90055-8"},{"key":"S0031182000063459_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(79)90114-0"},{"key":"S0031182000063459_ref012","doi-asserted-by":"publisher","DOI":"10.1038\/306389a0"},{"key":"S0031182000063459_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(79)90213-X"},{"key":"S0031182000063459_ref009","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/13.13.4661"},{"key":"S0031182000063459_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000049039"},{"key":"S0031182000063459_ref025","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1242\/jcs.5.1.163","article-title":"On the surface coat and flagellar adhesion in trypanosomes","volume":"5","author":"Vickerman","year":"1969","journal-title":"Journal of Cell Science"},{"key":"S0031182000063459_ref024","first-page":"1","article-title":"Antigenic variation in syringe passaged populations of Trypanosoma (Trypanozoon) brucei. 1. Rationalization of the experimental approach","volume":"55","author":"Van Meirvenne","year":"1975","journal-title":"Annals de la Soci\u00e9t\u00e9 belge M\u00e9dicine tropicale"},{"key":"S0031182000063459_ref010","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200004717X"},{"key":"S0031182000063459_ref020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/jcs.74.1.1","article-title":"Differentiation in Trypanosoma brucei: Host\u2013parasite cell junctions and their persistence during reacquisition of the variable antigen coat","volume":"74","author":"Tetley","year":"1985","journal-title":"Journal of Cell Science"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000063459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T23:44:02Z","timestamp":1633563842000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000063459\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,2]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,2]]}},"alternative-id":["S0031182000063459"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000063459","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,2]]}}}