{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:45:51Z","timestamp":1758127551076,"version":"3.37.0"},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":6153,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1992,6]]},"abstract":"<jats:p>Cats were repeatedly inoculated with infective larvae of<jats:italic>Brugia pahangi<\/jats:italic>. On parasitological grounds they could be divided into 5 groups. Group I \u2013 most cats (some 70%) became microfilaraemic (mf+) and retained high levels of microfilariae (mf) in their blood for over 2 years. In some Group I cats mf counts stabilized at high levels whilst in others mf counts continued to increase. Large numbers of fecund adult worms were recovered from their lymphatics. Adult counts were not made on the cats in the current experiments but over 100 adults have been recovered from \u2018super-susceptible\u2019 cats. Large amounts of<jats:italic>B. pahangi<\/jats:italic>adult antigen were consistently present in the serum of all Group I cats. About 30% of cats became amicrofilaraemic (mf\u2013). In these cats the peak mf levels were seldom above 10000 mf\/ml. Group II \u2013 these cats had less than 10 000 mf\/ml and low antigen levels. After more than 1 year of being repeatedly infected<jats:italic>B. pahangi<\/jats:italic>adult antigen slowly declined and eventually could no longer be detected in their serum and the number of mf declined very slowly after the fall in antigen levels. This shows that in Group II cats the adult worms die and as the cats are resistant to the development of the continuing weekly inoculation of L3 no new adults can develop. Group III \u2013 these cats became mf \u2013 during the first year of infection but remained<jats:italic>B. pahangi<\/jats:italic>antigen-positive for many weeks after this and, at autopsy, had living adults in their lymphatics. Group IV \u2013 in these cats there was a sudden decline in the number of mf, usually in the first year and after they have received a relatively small number of re-infections. Circulating adult<jats:italic>B. pahangi<\/jats:italic>antigen disappeared from the serum within a short time of the loss of mf and at autopsy no adult female worms were found. Group V \u2013 these cats do not become mf+ when infected. These groups are compared to the parasitological groups seen in areas endemic for infection with<jats:italic>Wuchereria bancrofti<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s0031182000063666","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:24:55Z","timestamp":1244211895000},"page":"415-420","source":"Crossref","is-referenced-by-count":17,"title":["Repeated infection of cats with<i>Brugia pahangi<\/i>: parasitological observations"],"prefix":"10.1017","volume":"104","author":[{"given":"D. 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Differential subclass recognition of parasite antigens correlates with different clinical manifestations of infection","volume":"139","author":"Hussain","year":"1987","journal-title":"Journal of Immunology"},{"key":"S0031182000063666_ref001","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-349-06136-5_6"},{"key":"S0031182000063666_ref005","doi-asserted-by":"publisher","DOI":"10.2307\/3277886"},{"key":"S0031182000063666_ref004","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000057127"},{"key":"S0031182000063666_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(72)90084-7"},{"key":"S0031182000063666_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(84)90309-2"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000063666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T23:22:48Z","timestamp":1739143368000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000063666\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,6]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,6]]}},"alternative-id":["S0031182000063666"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000063666","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"type":"print","value":"0031-1820"},{"type":"electronic","value":"1469-8161"}],"subject":[],"published":{"date-parts":[[1992,6]]}}}