{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:20:02Z","timestamp":1782548402309,"version":"3.54.5"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":6519,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1991,6]]},"abstract":"<jats:p>When sporozoites of <jats:italic>Eimeria tenella<\/jats:italic> were inoculated into an isolated horn of the bicornuate caecum of the domestic fowl, replicating infections, culminating in the production of oocysts, were found, almost exclusively, in the inoculated horn. In contrast, sporozoites of <jats:italic>E. tenella<\/jats:italic> introduced into the bloodstream via a superficial vein induced infections of equivalent intensity in both horns of the caecum. These findings are discussed with reference to (1) the detection (by tissue transfer) of infective sporozoites in samples of cardiac blood and vascular tissues taken within 3 to 18 h of the oral inoculation of oocysts, and (2) the (previously published) observation that the sporozoites of <jats:italic>E. tenella<\/jats:italic> are transported from the superficial epithelium of the caecum (site of invasion) to the crypts (site of initial development) within host intra-epithelial lymphocytes. We suggest that a local inflammatory response to the invasion of sporozoites may be responsible for their re-location in proximity to the site of entry. This could act by directing the homing (or retention) of the parasite-bearing lymphocytes, and\/or by providing a stimulus for the sporozoite to leave its transporting cell.<\/jats:p>","DOI":"10.1017\/s0031182000064258","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:32:56Z","timestamp":1244212376000},"page":"317-324","source":"Crossref","is-referenced-by-count":12,"title":["<i>Eimeria tenella<\/i>: localization of the sporozoites in the caecum of the domestic fowl"],"prefix":"10.1017","volume":"102","author":[{"given":"M. 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