{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T08:23:57Z","timestamp":1750494237318},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":5028,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>This paper demonstrates that the establishment and growth of the filarial nematode parasite, <jats:italic>Litomosoides carinii<\/jats:italic>, is reduced in pyridoxine-deficient cotton rats. Young cotton rats were assigned to one of three dietary groups: vitamin B6-deficient cotton rats (B6 \u2013AL) were fed a pyridoxine-free diet <jats:italic>ad libitum<\/jats:italic>; pair-fed controls (B6 + PF) were fed the same amount of pyridoxine-free diet as animals in the deficient group and given daily oral supplements of 100 \u03bcg pyridoxine; and pyridoxine-sufficient controls (B6 + AL) were fed the pyridoxine-free diet <jats:italic>ad libitum<\/jats:italic> and supplemented daily with 100 \u03bcg pyridoxine. Half of each group was infected with 50 L<jats:sub>3<\/jats:sub> of <jats:italic>L<\/jats:italic>. <jats:italic>carinii<\/jats:italic> by subcutaneous injection 8 weeks after the start of the experimental feeding period. B6-deficient cotton rats ate less (<jats:italic>P<\/jats:italic> &lt; 0\u00b7001) and gained less weight (P &lt; 0\u00b7001) than B6-supplemented controls. The levels of microfilaraemia in deficient animals, measured weekly throughout the experiment by taking blood smears, was significantly lower than in supplemented animals (P &lt; 0\u00b7001). The deficient rats became latent for <jats:italic>L. carinii<\/jats:italic> at 20 weeks post-infection, whereas there was patent microfilaraemia in rats in the other dietary groups until the end of the experiment. Smaller (<jats:italic>P<\/jats:italic> &lt; 0\u00b7001) and fewer (<jats:italic>P<\/jats:italic> &lt; 0\u00b705) adult worms were recovered from the pleural and abdominal cavities of deficient animals than from either pair-fed or sufficient controls at autopsy 28 weeks post-infection.<\/jats:p>","DOI":"10.1017\/s0031182000064660","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T09:46:07Z","timestamp":1244195167000},"page":"111-118","source":"Crossref","is-referenced-by-count":5,"title":["The host-parasite relationships in pyridoxine (vitamin B6) deficient cotton rats infected with <i>Litomosoides carinii<\/i> (Nematoda: Filaroidea)"],"prefix":"10.1017","volume":"111","author":[{"given":"M. A.","family":"Beg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Fistein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Storey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000064660_ref032","volume-title":"Tropical Diseases Research 1989\u20131990","year":"1991"},{"key":"S0031182000064660_ref020","volume-title":"Interactions of Nutrition and Infection","author":"Scrimshaw","year":"1968"},{"key":"S0031182000064660_ref016","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197905173002004"},{"key":"S0031182000064660_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91649-3"},{"key":"S0031182000064660_ref024","doi-asserted-by":"publisher","DOI":"10.1007\/BF00927666"},{"key":"S0031182000064660_ref013","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124393"},{"key":"S0031182000064660_ref012","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1976.11687126"},{"key":"S0031182000064660_ref010","first-page":"346","article-title":"The effect of malnutrition and filarial infection in albino rats","volume":"654","author":"Jayapragasam","year":"1977","journal-title":"Indian Journal of Medical Research"},{"key":"S0031182000064660_ref006","doi-asserted-by":"publisher","DOI":"10.2307\/3275988"},{"key":"S0031182000064660_ref002","doi-asserted-by":"publisher","DOI":"10.1300\/J053v02n03_04"},{"key":"S0031182000064660_ref001","unstructured":"Beg M. A. (1993). Host-parasite relationships in Vitamin B6 deficient cotton rats (Sigmodon hispidus) infected with Litomosoides carinii. Ph.D. thesis, University of Salford."},{"key":"S0031182000064660_ref028","volume-title":"Nutrition and Disease in Experimental Animals","author":"Ward","year":"1970"},{"key":"S0031182000064660_ref007","volume-title":"Immunology of Nutritional Disorders","author":"Chandra","year":"1980"},{"key":"S0031182000064660_ref027","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00007951"},{"key":"S0031182000064660_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(80)90055-3"},{"key":"S0031182000064660_ref011","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1949.11685410"},{"key":"S0031182000064660_ref008","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/51.3.446"},{"key":"S0031182000064660_ref005","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1946.11685283"},{"key":"S0031182000064660_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(81)90072-9"},{"key":"S0031182000064660_ref022","first-page":"S35","article-title":"Malnutrition in experimental filariasis","volume":"82","author":"Storey","year":"1981","journal-title":"Parasitology"},{"key":"S0031182000064660_ref029","doi-asserted-by":"publisher","DOI":"10.1038\/258113a0"},{"key":"S0031182000064660_ref030","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00010749"},{"key":"S0031182000064660_ref021","first-page":"55","article-title":"Pyridoxine and fat metabolism","volume":"8","author":"Sherman","year":"1950","journal-title":"Vitamins and Hormones \u2013 Advances in Research and Applications"},{"key":"S0031182000064660_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(78)90152-9"},{"key":"S0031182000064660_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(80)90017-X"},{"key":"S0031182000064660_ref025","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000075570"},{"key":"S0031182000064660_ref023","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000056328"},{"key":"S0031182000064660_ref033","first-page":"530","article-title":"Experimental infection of gerbils with Litomosoides carinii via intravenous infection","volume":"23","author":"Zein-Eldin","year":"1965","journal-title":"Texas Reports of Biology and Medicine"},{"key":"S0031182000064660_ref031","first-page":"92","article-title":"Die Regulation der Parasitaemie bei Filararien (Litomosoides carinii, Nematoda, Filarioidea)","volume":"33","author":"Wenk","year":"1970","journal-title":"Zoologischer Anzeiger"},{"key":"S0031182000064660_ref026","volume-title":"Dipetolonema viteae Infected Mongolian Jirds as a Routine Model for Screening Antifilarial Agents","author":"Striebel","year":"1985"},{"key":"S0031182000064660_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60451-0"},{"key":"S0031182000064660_ref015","doi-asserted-by":"publisher","DOI":"10.1007\/BF00927743"},{"key":"S0031182000064660_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00013146"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000064660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T17:34:09Z","timestamp":1557768849000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000064660\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,7]]}},"alternative-id":["S0031182000064660"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000064660","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7]]}}}