{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:02:04Z","timestamp":1776988924470,"version":"3.51.4"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":4844,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>A temporal study of the effects on the tegument of <jats:italic>Schistosoma mansoni<\/jats:italic> adult worm following <jats:italic>in vivo<\/jats:italic> praziquantel and oxamniquine treatment was performed. Drug-induced damage to the tegument, exposure of surface antigens and attachment of host antibody occurred rapidly, within 1 h, following praziquantel treatment. Oxamniquine-treated worms required 4\u20138 days for these effects to be apparent. The 2 drugs differed in the degree and sites of damage on the worm surface. The administration of 2 different polyspecific rabbit sera with drug significantly increased the efficacy of praziquantel when administered with the drug, but not when given 6\u20139 days after drug treatment. In contrast, only 1 serum was synergistic with oxamniquine when administered with drug and both sera were synergistic when given 6\u20139 days after drug treatment. The effect of immune killing of drug-treated worms is discussed.<\/jats:p>","DOI":"10.1017\/s0031182000065069","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T09:37:01Z","timestamp":1244194621000},"page":"47-58","source":"Crossref","is-referenced-by-count":38,"title":["Temporal differences in praziquantel- and oxamniquine-induced tegumental damage to adult <i>Schistosoma mansoni<\/i>: implications for drug-antibody synergy"],"prefix":"10.1017","volume":"112","author":[{"given":"P. G.","family":"Fallon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"Fookes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. A.","family":"Wharton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000065069_ref012","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000051568"},{"key":"S0031182000065069_ref011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1994.tb00307.x"},{"key":"S0031182000065069_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(85)90041-4"},{"key":"S0031182000065069_ref005","first-page":"507","article-title":"Anti-schistosome chemotherapy enhanced by antibodies specific for a parasite esterase","volume":"65","author":"Doenhoff","year":"1988","journal-title":"Immunology"},{"key":"S0031182000065069_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(92)90070-I"},{"key":"S0031182000065069_ref002","first-page":"815","article-title":"Schistosoma mansoni: tegumental surface alterations following oxamniquine treatment of infected mice","volume":"19","author":"Amin","year":"1989","journal-title":"Journal of the Egyptian Society of Parasitology"},{"key":"S0031182000065069_ref015","first-page":"544","article-title":"In vivo and in vitro experiments on the effects of praziquantel on Schistosoma mansoni: a light and electron microscopic study","volume":"31","author":"Mehlhorn","year":"1981","journal-title":"tArzneimittel-Forschung"},{"key":"S0031182000065069_ref018","first-page":"797","article-title":"Scanning electron microscopy of the tegumental surface of in vivo treated Schistosoma mansoni (Saudi Arabian geographic strain) with oxamniquine and praziquantel","volume":"21","author":"Shalaby","year":"1991","journal-title":"Journal of the Egyptian Society of Parasitology"},{"key":"S0031182000065069_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(93)90138-6"},{"key":"S0031182000065069_ref001","first-page":"17","article-title":"Drugs for parasitic diseases","volume":"34","author":"Abramowicz","year":"1992","journal-title":"The Medical Letter"},{"key":"S0031182000065069_ref008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1995.tb01024.x"},{"key":"S0031182000065069_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200007534X"},{"key":"S0031182000065069_ref016","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1990.tb00958.x"},{"key":"S0031182000065069_ref010","doi-asserted-by":"publisher","DOI":"10.1007\/BF00933013"},{"key":"S0031182000065069_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(89)90505-1"},{"key":"S0031182000065069_ref009","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200006460X"},{"key":"S0031182000065069_ref019","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000086248"},{"key":"S0031182000065069_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(87)90360-9"},{"key":"S0031182000065069_ref013","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/1982573285"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000065069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T15:39:44Z","timestamp":1557761984000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000065069\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,1]]}},"alternative-id":["S0031182000065069"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000065069","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,1]]}}}