{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T02:27:27Z","timestamp":1697509647974},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":4844,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The human hookworm<jats:italic>Necator americanus<\/jats:italic>appears to have evolved a number of complementary strategies to overcome the host's haemostatic processes. These include the inhibition of blood coagulation, platelet aggregation and mediator release, and the secretion of fibrinogenolytic enzymes. These strategies presumably allow the parasite to establish the chronic infections so often documented in human populations.<\/jats:p>","DOI":"10.1017\/s0031182000065100","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T13:37:01Z","timestamp":1244209021000},"page":"81-87","source":"Crossref","is-referenced-by-count":20,"title":["The anti-haemostatic strategies of the human hookworm<i>Necator americanus<\/i>"],"prefix":"10.1017","volume":"112","author":[{"given":"B. A.","family":"Furmidge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. A.","family":"Horn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. I.","family":"Pritchard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000065100_ref015","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1974.23.1046"},{"key":"S0031182000065100_ref026","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110448"},{"key":"S0031182000065100_ref011","doi-asserted-by":"publisher","DOI":"10.1084\/jem.157.5.1594"},{"key":"S0031182000065100_ref022","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1016\/S0021-9258(18)32568-7","article-title":"Identification of two structurally and functionally distinct sites on human platelet membrane glycoprotein IIb-IIIa using monoclonal antibodies","volume":"258","author":"McEver","year":"1983","journal-title":"Journal of Biological Chemistry"},{"key":"S0031182000065100_ref008","first-page":"10729","article-title":"Role of fibrinogen \u03b1 and \u03b3 chain sites in platelet aggregation","volume":"89","author":"Farrell","year":"1992","journal-title":"Biochemistry"},{"key":"S0031182000065100_ref030","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1055\/s-0038-1646195","article-title":"Regulation of platelet anchorage and signalling by integrin \u03b1IIb\u03b23","volume":"70","author":"Shattil","year":"1993","journal-title":"Thrombosis and Haemostasis"},{"key":"S0031182000065100_ref024","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a131840"},{"key":"S0031182000065100_ref013","doi-asserted-by":"crossref","first-page":"7343","DOI":"10.1016\/S0021-9258(17)39614-X","article-title":"Isolation and characterisation of a proteolytic enzyme from the adult hookworm Ancylostoma caninum","volume":"260","author":"Hotez","year":"1985","journal-title":"Journal of Biological Chemistry"},{"key":"S0031182000065100_ref029","first-page":"513","article-title":"Thrombolytics and anti-coagulants from leeches","volume":"9","author":"Sawyer","year":"1991","journal-title":"Biotechnology"},{"key":"S0031182000065100_ref005","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.13.6152"},{"key":"S0031182000065100_ref031","doi-asserted-by":"crossref","first-page":"11107","DOI":"10.1016\/S0021-9258(17)39154-8","article-title":"Changes in the platelet membrane glycoprotein IIb\/IIIa complex during platelet activation","volume":"260","author":"Shattil","year":"1985","journal-title":"Journal of Biological Chemistry"},{"key":"S0031182000065100_ref001","first-page":"41","article-title":"Inactivation of platelet-activating factor by a putative acetylhydrolase from the gastrointestinal nematode parasite Nippostrongylus brasiliensis","volume":"75","author":"Blackburn","year":"1992","journal-title":"Immunology"},{"key":"S0031182000065100_ref002","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1982.tb01580.x"},{"key":"S0031182000065100_ref003","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1993.tb00600.x"},{"key":"S0031182000065100_ref004","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/167.6.1474"},{"key":"S0031182000065100_ref033","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1987.tb01434.x"},{"key":"S0031182000065100_ref006","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1055\/s-0038-1661063","article-title":"The anticoagulant effects of hookworm, Ancylostoma ceylanicum: Observations in human and dog blood in vitro and infected dogs in vivo","volume":"51","author":"Carroll","year":"1984","journal-title":"Thrombosis and Haemostasis"},{"key":"S0031182000065100_ref007","doi-asserted-by":"publisher","DOI":"10.2307\/3276520"},{"key":"S0031182000065100_ref010","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198908000-00009"},{"key":"S0031182000065100_ref027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1974.tb06660.x"},{"key":"S0031182000065100_ref012","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0695-68"},{"key":"S0031182000065100_ref014","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1055\/s-0038-1646371","article-title":"The complexity of platelet adhesion to extracellular matrices","volume":"66","author":"Hynes","year":"1991","journal-title":"Thrombosis and Haemostasis"},{"key":"S0031182000065100_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(80)90098-5"},{"key":"S0031182000065100_ref009","doi-asserted-by":"crossref","first-page":"11891","DOI":"10.1016\/S0021-9258(17)38962-7","article-title":"The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets","volume":"260","author":"Gartner","year":"1985","journal-title":"Journal of Biological Chemistry"},{"key":"S0031182000065100_ref017","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/7.5.625"},{"key":"S0031182000065100_ref018","first-page":"173","article-title":"The presence of a substance inhibiting the coagulation of the blood in Ancylostoma","volume":"7","author":"Loeb","year":"1904","journal-title":"Proceedings of the Pathological Society"},{"key":"S0031182000065100_ref019","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1990.tb02498.x"},{"key":"S0031182000065100_ref020","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin-phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"Journal of Biological Chemistry"},{"key":"S0031182000065100_ref021","first-page":"842","article-title":"Fibrinogen degradation by hementin, a fibrinogenolytic anticoagulant from the salivary glands of the leech Haementeria ghilianii","volume":"104","author":"Malinconico","year":"1984","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"S0031182000065100_ref023","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.9.4033"},{"key":"S0031182000065100_ref025","doi-asserted-by":"crossref","first-page":"10008","DOI":"10.1016\/S0021-9258(17)36982-X","article-title":"A hookworm glycoprotein that inhibits neutrophil function is a ligand of the integrin CD 11b\/CD 18","volume":"269","author":"Moyle","year":"1994","journal-title":"Journal of Biological Chemistry"},{"key":"S0031182000065100_ref028","first-page":"11766","article-title":"Binding of the snake venom-derived proteins applagin and echistatin to the arginine-glycine-aspartic acid recognition site(s) as platelet glycoprotein IIb\/IIIa complex inhibits receptor function","volume":"265","author":"Savage","year":"1990","journal-title":"Journal of Biochemistry"},{"key":"S0031182000065100_ref032","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1152\/ajplegacy.1971.220.4.922","article-title":"Anticoagulant activity of dog hookworm","volume":"4","author":"Spellman","year":"1971","journal-title":"American Journal of Physiology"},{"key":"S0031182000065100_ref034","first-page":"21","article-title":"Proteolytic activity in extracts of the oesophagus of adults of Ancylostoma caninum and the effect of immune serum on this activity","volume":"7","author":"Thorson","year":"1955","journal-title":"Journal of Parasitology"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000065100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T23:01:30Z","timestamp":1633561290000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000065100\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,1]]}},"alternative-id":["S0031182000065100"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000065100","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,1]]}}}