{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:18:23Z","timestamp":1762251503472},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":4844,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>We previously reported that genes within the major histocompatibility complex influence the intensity of<jats:italic>Taenia crassiceps<\/jats:italic>murine cysticercosis. This genetic control, readily apparent in mice of BALB background, was further studied in<jats:italic>H-2<\/jats:italic>congenic and recombinant B10 mice as well as in BALB\/c substrains differing in expression of Qa-2 antigens. Similarly low parasite numbers were found in all B10-derived strains infected, regardless of<jats:italic>H-2<\/jats:italic>haplotype, indicating that the effect of<jats:italic>H-2<\/jats:italic>genes in controlling susceptibility is overridden in mice of B10 background. BALB\/c substrains differed significantly in susceptibility. BALB\/cAnN was highly susceptible, whereas BALB\/cJ, in contrast, was highly resistant and BALB\/cByJ showed intermediate susceptibility. Susceptibility or resistance in BALB\/c substrains may be associated to differences known to distinguish them, such as serum testosterone levels and Qa-2 protein expression. In bidirectional F1 hybrids of C57BL\/6J and BALB\/cAnN resistance to cysticercosis was inherited as a dominant autosomal trait. In F1 hybrids of BALB\/cJ with BALB\/cAnN, BALB\/cByJ and BALB.K resistance was also inherited as a dominant trait. However, in (BALB\/cAnN \u00d7 BALB\/cByJ)F1 and (BALB\/cAnN \u00d7 BALE.K)F1 hybrids, dominant susceptibility to cysticercosis was observed.<\/jats:p>","DOI":"10.1017\/s003118200006515x","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T13:37:01Z","timestamp":1244209021000},"page":"119-124","source":"Crossref","is-referenced-by-count":32,"title":["Genetic control of susceptibility to<i>Taenia 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