{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T10:13:30Z","timestamp":1705227210564},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":8345,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1986,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Antigenic variation in the ILDar 1 serodeme of the naturally rodent-infective stock of West African<jats:italic>Trypanosoma vivax<\/jats:italic>has been investigated following cyclical transmission. The immunofluorescent and immune lysis tests were employed with a panel of 39 variant-specific mouse antisera. When antigenically homogeneous, or mixed, populations were transmitted by tsetse flies to goats, the first peak parasitaemias arising in the goats were antigenic mixtures (up to 9 major, and several minor variants being recognized in some cases) from which the ingested variant was absent. Although first peak parasitaemias in similarly infected goats showed some variants in common, there was no obvious relationship between the VAT profiles in different goats. When these populations were expanded in irradiated mice, VAT heterogeneity was maintained with a tendency towards the development of predominant variants in some, but not all, instances. Six additional variants, derived following the growth of bloodstream form ILDat 1\u00b79 in 37\u00b0C culture, were also represented in goat and mouse populations. Two further variants, isolated after cyclical development of ILDat 1\u00b79-derived trypanosomes<jats:italic>in vitro<\/jats:italic>, were not present in the early parasitaemias in goats and mice.<\/jats:p>","DOI":"10.1017\/s003118200006546x","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T16:20:46Z","timestamp":1244218846000},"page":"581-593","source":"Crossref","is-referenced-by-count":13,"title":["Further studies of cyclical transmission and antigenic variation of the ILDar 1 serodeme of<i>Trypanosoma vivax<\/i>"],"prefix":"10.1017","volume":"92","author":[{"given":"P. R.","family":"Gardiner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Thatthi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Gathuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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L. W. (1980). Host\u2013parasite relationships in Trypanosoma (Duttonella) vivax with special reference to the influence of antigenic variation. Ph.D. thesis, University of Utrecht, Holland."},{"key":"S003118200006546X_ref025","unstructured":"Mahan S. M. (1984). Analysis of the humoral and cellular immune responses in C3H\/He (susceptible) and C57 BL\/6 (resistant) mice infected with the West African strain of T. vivax cattle parasites. Ph.D. thesis, University of Birmingham."},{"key":"S003118200006546X_ref022","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1974.11686975"},{"key":"S003118200006546X_ref021","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1972.11686829"},{"key":"S003118200006546X_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(79)90119-X"},{"key":"S003118200006546X_ref018","article-title":"Complete cyclic development of Trypanosoma vivax in vitro","volume":"30","author":"Hirumi","year":"1983","journal-title":"Journal of Protozoology"},{"key":"S003118200006546X_ref003","first-page":"135","article-title":"In vitro cultivation of animal-infective forms of a West African Trypanosoma vivax stock","volume":"39","author":"Brun","year":"1982","journal-title":"Acta Tropica"},{"key":"S003118200006546X_ref023","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(70)90120-7"},{"key":"S003118200006546X_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(71)90269-0"},{"key":"S003118200006546X_ref001","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000063447"},{"key":"S003118200006546X_ref026","doi-asserted-by":"publisher","DOI":"10.1017\/S0007485300010944"},{"key":"S003118200006546X_ref028","first-page":"19","article-title":"Analysis of the variable antigen composition of Trypanosoma brucei brucei metacyclic trypanosomes using monoclonal antibodies","volume":"40","author":"Nantulya","year":"1983","journal-title":"Acta Tropica"},{"key":"S003118200006546X_ref015","unstructured":"Gardiner P. R. , Thatthi R. , MoLoo S. K. & Gray A. R. (1984). Antigenic variation in the ILDar 1 serodeme of Trypanosoma vivax. Proceedings of the 33rd Annual Meeting of the American Society of Tropical Medicine and Hygiene, Baltimore, MD, USA Abstract no. 80."},{"key":"S003118200006546X_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(63)90292-7"},{"key":"S003118200006546X_ref007","doi-asserted-by":"publisher","DOI":"10.1007\/BF02360116"},{"key":"S003118200006546X_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(81)90126-0"},{"key":"S003118200006546X_ref016","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000063460"},{"key":"S003118200006546X_ref027","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1982.11687543"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S003118200006546X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T14:37:39Z","timestamp":1685025459000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S003118200006546X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,6]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1986,6]]}},"alternative-id":["S003118200006546X"],"URL":"https:\/\/doi.org\/10.1017\/s003118200006546x","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,6]]}}}