{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:21:04Z","timestamp":1761675664055},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":4784,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1996,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>In order to study the effects of acclimatization of<jats:italic>Plasmodium<\/jats:italic>in \u03b2-thalassaemic mice, we used a mouse model of \u03b2-thalassaemia (DBA\/2J\/\u03b2-thal\/\u03b2-thal), similar to that observed in humans. We acclimatized 3 rodent malarias (<jats:italic>P. berghei, P. chabaudi<\/jats:italic>and<jats:italic>P. yoelii<\/jats:italic>) in DBA\/2J and DBA\/2J\/\u03b2-thal\/\u03b2-thal mice lines, by 4 intraperitoneal serial transfers. All 3 rodent malarias developed in red blood cells of \u03b2-thalassaemic mice without losing their virulence. There was no delay in infection and peaks of parasitaemia were similar in \u03b2-thalassaemic and normal mice. The mortality occurred earlier in \u03b2-thalassaemic mice than in control mice for<jats:italic>P. berghei<\/jats:italic>and<jats:italic>P. chabaudi<\/jats:italic>. This difference was more pronounced for<jats:italic>P. yoelii<\/jats:italic>NS where normal mice did not die. These results could be explained by a failure of erythropoiesis in \u03b2-thalassaemic mice, which are unable to compensate for the destruction of red blood cells by the parasites, and the mice died of anaemia. Ultrastructural examination of the rodent malaria parasites in \u03b2-thalassaemic RBC showed a normal development even in the presence of Heinz bodies. In conclusion, no effective protection against malaria was provided by the \u03b2-thalassaemia in this mouse model.<\/jats:p>","DOI":"10.1017\/s0031182000065781","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T13:34:39Z","timestamp":1244208879000},"page":"269-276","source":"Crossref","is-referenced-by-count":4,"title":["The course of<i>Plasmodium berghei, P. chabaudi<\/i>and<i>P. yoelii<\/i>infections in \u03b2-thalassaemic mice"],"prefix":"10.1017","volume":"112","author":[{"given":"G.","family":"Clarebout","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Gamain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Slomianny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Camus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Dive","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000065781_ref005","doi-asserted-by":"publisher","DOI":"10.1038\/280245a0"},{"key":"S0031182000065781_ref013","first-page":"321","article-title":"Innate resistance to malaria: the intraerythrocytic 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