{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:57:30Z","timestamp":1770721050101,"version":"3.49.0"},"reference-count":43,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":4784,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1996,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Mice inoculated with microfilariae of the filarial nematode<jats:italic>Onchocerca lienalis<\/jats:italic>clear their parasites over a period of 3\u20134 months and are highly resistant to re-infection. We have investigated the comparative roles of the eosinophil, macrophage and neutrophil in effecting this parasite clearance, employing agents specifically to perturb cell function<jats:italic>in vivo<\/jats:italic>. Using the anti-IL-5 monoclonal antibody TRFK-5, we show that eosinophils are of primary importance in effecting resistance to re-infection. Ablation of macrophages (with carbon) and neutrophils (with the monoclonal antibody NIMP-R14) had no effect on parasite clearance following re-infection. Neutralization of these 3 cell types during a primary infection showed that while the removal of both eosinophils and macrophages caused a small but significant delay in parasite clearance, the depletion of neutrophils had no effect. This report describes the first direct evidence for eosinophil-mediated killing of microfilariae<jats:italic>in vivo<\/jats:italic>, and is consistent with Th-2 cell responses previously described in this model.<\/jats:p>","DOI":"10.1017\/s0031182000065847","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T13:34:39Z","timestamp":1244208879000},"page":"323-329","source":"Crossref","is-referenced-by-count":45,"title":["Eosinophils are the major effector cells of immunity to microfilariae in a mouse model of onchocerciasis"],"prefix":"10.1017","volume":"112","author":[{"given":"S. G.","family":"Folkard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Hogarth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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