{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T09:12:47Z","timestamp":1758273167166},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":4784,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1996,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Worm expulsion of, and IgE and interferon (IFN)-\u03b3 responses to,<jats:italic>Nippostrongylus brasiliensis<\/jats:italic>were studied in 2 rat strains, Brown Norway (BN) and Fischer (F)-344. BN rats expelled the majority of worms by day 14 post-infection (p.i.) with approximately 6% of worms surviving for at least 3 weeks. In F-344 rats, worm expulsion was delayed by 2 days relative to that in BN, while the numbers of residual worms were significantly fewer than in BN, suggesting that different immune mechanisms are involved in early and late phases of immunity. Total serum IgE, as well as<jats:italic>in vitro<\/jats:italic>IgE production by mesenteric lymph node (MLN) cells, was increased 2 weeks p.i., the levels being markedly higher in BN than in F-344 rats. Serum rat mast cell protease II was also increased more significantly in BN than in F-344 rats. In contrast, production of IgG2a and IFN-\u03b3 by MLN and spleen cells was found to be higher in F-344 than in BN rats. These results indicate that the early worm expulsion is correlated with the host IgE and mast cell responsiveness, whereas the persistence of infection in the late period may be controlled by different immune mechanisms.<\/jats:p>","DOI":"10.1017\/s0031182000065860","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T13:34:39Z","timestamp":1244208879000},"page":"339-345","source":"Crossref","is-referenced-by-count":6,"title":["Dissociation of early and late protective immunity to the nematode<i>Nippostrongylus brasiliensis<\/i>in Brown Norway and Fischer-344 rats"],"prefix":"10.1017","volume":"112","author":[{"given":"R.","family":"Uchikawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Tegoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Kamata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Arizono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000065860_ref028","first-page":"298","article-title":"IgE and IgG2a antibody responses are induced by different antigen groups of the nematode Nippostrongylus brasiliensis in rats","volume":"78","author":"Yamada","year":"1993","journal-title":"Immunology"},{"key":"S0031182000065860_ref027","doi-asserted-by":"publisher","DOI":"10.1038\/312450a0"},{"key":"S0031182000065860_ref023","first-page":"427","article-title":"IgE antibody production is associated with suppressed interferon-\u03b3 levels in mesenteric lymph nodes of rats infected with the nematode Nippostrongylus brasiliensis","volume":"82","author":"Uchikawa","year":"1994","journal-title":"Immunology"},{"key":"S0031182000065860_ref018","doi-asserted-by":"publisher","DOI":"10.1007\/BF01540344"},{"key":"S0031182000065860_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(71)90021-X"},{"key":"S0031182000065860_ref016","first-page":"245","article-title":"Reagin synthesis in inbred strains of rats","volume":"27","author":"Murphey","year":"1974","journal-title":"Immunology"},{"key":"S0031182000065860_ref015","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.07.040189.001045"},{"key":"S0031182000065860_ref014","first-page":"277","article-title":"Immune reaction in mucous membranes. 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