{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T11:23:23Z","timestamp":1708860203762},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":4662,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1996,7]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>A study to compare the effects of different frequencies of targeted chemotherapy with levamisole (Ketrax: JAGAL Pharma, Lagos, Zeneca Pharmaceuticals UK) as an action for the control of <jats:italic>Ascaris lumbricoides<\/jats:italic> was carried out in 3 communities in rural Oyo State, Nigeria. The targeted group comprised children, aged 5 to 15 years, attending primary school within their village. Treatment was provided within the school with the assistance of the school teachers. Three frequencies of targeted treatment were offered. In one village targeted treatment was provided on 1 occasion in 1 year, in another village at two 6-monthly intervals and in the third village every 4 months. Prevalence and intensity (e.p.g.) of <jats:italic>A. lumbricoides<\/jats:italic> infection were determined immediately before and after the period of intervention using a modified Kato\u2013Katz technique. In the villages which received treatment once and at 6-monthly intervals, a reduction in post-treatment intensity of <jats:italic>A. lumbricoides<\/jats:italic> was observed in the total population but this failed to attain statistical significance. In contrast, within the village which received 4-monthly targeted chemotherapy, a significant reduction in post-treatment intensity of <jats:italic>A. lumbricoides<\/jats:italic> was observed in the total population and in the targeted children. In general, reductions in the intensity of <jats:italic>A. lumbricoides<\/jats:italic> after intervention were not particularly pronounced in untreated children (aged 0\u20134 years) even in the 4-monthly targeted village, whereas in untreated adults, reductions approached statistical significance in villages which received targeted treatment once and at 4-monthly intervals.<\/jats:p>","DOI":"10.1017\/s0031182000066300","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T09:30:04Z","timestamp":1244194204000},"page":"87-95","source":"Crossref","is-referenced-by-count":18,"title":["Targeted anthelminthic treatment of school children: effect of frequency of application on the intensity of <i>Ascaris lumbricoides<\/i> infection in children from rural Nigerian villages"],"prefix":"10.1017","volume":"113","author":[{"given":"C. V.","family":"Holland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. O.","family":"Asaolu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. W. T.","family":"Crompton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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Diagnostic techniques for intestinal parasitic infections (IPI) applicable to primary health care (PHC) services. WHO\/P.D.P.\/85.2, 1211, Geneva 27, Switzerland."},{"key":"S0031182000066300_ref004","first-page":"279","article-title":"The prevalence and intensity of soil-transmitted helminthiases in rural communities in Southern Nigeria","volume":"86","author":"Asaolu","year":"1992","journal-title":"Annals of Tropical Medicine and Hygiene"},{"key":"S0031182000066300_ref013","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200005873X"},{"key":"S0031182000066300_ref025","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197911013011804"},{"key":"S0031182000066300_ref010","first-page":"169","volume-title":"Ascariasis and its Prevention and Control","author":"Cabrera","year":"1989"},{"key":"S0031182000066300_ref015","first-page":"177","volume-title":"Hookworm Disease: Current Status and New Directions","author":"Keymer","year":"1990"},{"key":"S0031182000066300_ref018","volume-title":"Impact of Helminth Infections on Human Nutritiona","author":"Stephenson","year":"1987"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000066300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T17:10:52Z","timestamp":1557681052000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000066300\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,7]]}},"alternative-id":["S0031182000066300"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000066300","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,7]]}}}