{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T09:57:47Z","timestamp":1704967067165},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":15589,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1966,8]]},"abstract":"<jats:p>When infected with equal numbers of eggs of <jats:italic>Amplicaecum robertsi<\/jats:italic> normal male mice harboured more larvae than normal females. Treatment of the mice with thiouracil and thyroxine eliminated the differences between the sizes of the worm populations shown between the sexes in normal mice.<\/jats:p><jats:p>Thiouracil treatment increased the susceptibility of mice to <jats:italic>A. robertsi<\/jats:italic> infection, but caused a stunting of the larvae. Thyroxine treatment had no effect on the host\u2013parasite relationship.<\/jats:p><jats:p>It is suggested that the differential ability of the larvae to hatch, penetrate the tissues of the host and migrate to the liver in thiouracil- and thyroxine-treated mice was responsible for the differences in the sizes of the larval populations observed.<\/jats:p><jats:p>This investigation was carried out during the tenure of a Senior Research Fellowship from the Wool Research Board of Australia. I should like to thank Professor J. F. A. Sprent for his continued interest and Mr C. Wilkinson for his careful assistance.<\/jats:p>","DOI":"10.1017\/s003118200006892x","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T17:23:32Z","timestamp":1244222612000},"page":"425-429","source":"Crossref","is-referenced-by-count":9,"title":["The effects of thiouracil and thyroxine on the host-parasite relationship of <i>Amplicaecum robertsi<\/i> Sprent &amp; Mines, 1960, in the mouse"],"prefix":"10.1017","volume":"56","author":[{"given":"Colin","family":"Dobson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S003118200006892X_ref007","doi-asserted-by":"publisher","DOI":"10.3382\/ps.0270818"},{"key":"S003118200006892X_ref002","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200006889X"},{"key":"S003118200006892X_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(64)90016-5"},{"key":"S003118200006892X_ref003","first-page":"498","volume-title":"Immunology for Students of Medicine","author":"Humphrey","year":"1964"},{"key":"S003118200006892X_ref004","first-page":"24","article-title":"The effect of thyroid and thiouracil on the natural resistance of mice to infections with Hymenolepis","volume":"33","author":"Larsh","year":"1947","journal-title":"J. Parasit."},{"key":"S003118200006892X_ref005","doi-asserted-by":"publisher","DOI":"10.2307\/3273175"},{"key":"S003118200006892X_ref008","doi-asserted-by":"publisher","DOI":"10.2307\/3273300"},{"key":"S003118200006892X_ref009","first-page":"473","article-title":"The effect of thiouracil-induced hypothyroidism on the resistance of chicks artificially infected with Eimeria tenella","volume":"112","author":"Wheeler","year":"1948","journal-title":"J. Am. vet. med. Ass."},{"key":"S003118200006892X_ref010","first-page":"12","article-title":"Thyroid abnormalities as a possible factor in trichostrongylidosis","volume":"35","author":"Whitlock","year":"1949","journal-title":"J. Parasit."},{"key":"S003118200006892X_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000072498"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S003118200006892X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T20:50:25Z","timestamp":1559508625000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S003118200006892X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1966,8]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1966,8]]}},"alternative-id":["S003118200006892X"],"URL":"https:\/\/doi.org\/10.1017\/s003118200006892x","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1966,8]]}}}