{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:10:03Z","timestamp":1739146203781,"version":"3.37.0"},"reference-count":8,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":14950,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1968,5]]},"abstract":"<jats:p>When serotonin is injected intravenously into certain animals containing microfilariae it causes a sharp short rise in the microfilaria count in the blood, i.e. liberation of microfilariae from the lungs. This happens in the case of<jats:italic>Dirofilaria immitis<\/jats:italic>(in dog),<jats:italic>D. repens<\/jats:italic>(in dog),<jats:italic>Loa loa<\/jats:italic>(in drill),<jats:italic>Edesonfilaria malayensis<\/jats:italic>and another Dirofilaria-like microfilaria (in monkey),<jats:italic>Monnigofilaria setariosa<\/jats:italic>(in mongoose), and<jats:italic>Dipetalonema gracile<\/jats:italic>(in squirrel monkey); but not with<jats:italic>Dip. witei<\/jats:italic>(in gerbil) and<jats:italic>Litomosoides carinii<\/jats:italic>in cotton rats.<\/jats:p><jats:p>This action (upon<jats:italic>D. immitis<\/jats:italic>) is not inhibited by atropine. Administration of reserpine, harmine or harmaline to dogs did not exert any definite action on the microfilaria count of<jats:italic>D. immitis<\/jats:italic>. Serotonin had no obvious effect on the<jats:italic>in vitro<\/jats:italic>activity of microfilariae of<jats:italic>L. loa<\/jats:italic>or<jats:italic>E. malayensis<\/jats:italic>. Melatonin had no action<jats:italic>in vivo<\/jats:italic>upon any of the above microfilariae.<\/jats:p><jats:p>The action of serotonin upon microfilariae<jats:italic>in vivo<\/jats:italic>is similar to that of acetylcholine but it is not identical with it since the sensitivity of<jats:italic>Dip. gracile<\/jats:italic>and<jats:italic>Dip. witei<\/jats:italic>to the two compounds is different.<\/jats:p><jats:p>Apparently this action is not involved in the production of the 24 h periodicity shown by many microfilariae. It may depend upon disturbance of the normal neuromuscular mechanisms of the microfilariae by which they are retained in the small vessels of the lungs.<\/jats:p>","DOI":"10.1017\/s0031182000069420","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T17:17:48Z","timestamp":1244222268000},"page":"393-402","source":"Crossref","is-referenced-by-count":6,"title":["The action of serotonin (5-hydroxytryptamine)<i>in vivo<\/i>upon the microfilariae of<i>Dirofilaria, Loa<\/i>and five other species"],"prefix":"10.1017","volume":"58","author":[{"given":"Frank","family":"Hawking","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Gammage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000069420_ref002","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1967.0079"},{"key":"S0031182000069420_ref007","doi-asserted-by":"publisher","DOI":"10.2307\/3274565"},{"key":"S0031182000069420_ref001","first-page":"151","article-title":"Recent research in the field of 5-hydroxytryptamine and related indolealkylamines","volume":"3","author":"Erspamer","year":"1961","journal-title":"Prog. 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Ther."},{"key":"S0031182000069420_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(65)90136-7"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000069420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T23:33:50Z","timestamp":1739144030000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000069420\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,5]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1968,5]]}},"alternative-id":["S0031182000069420"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000069420","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"type":"print","value":"0031-1820"},{"type":"electronic","value":"1469-8161"}],"subject":[],"published":{"date-parts":[[1968,5]]}}}