{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:07:46Z","timestamp":1758636466631},"reference-count":47,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":15316,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1967,5]]},"abstract":"<jats:p>Sheep infected with <jats:italic>Oesophagostomum columbianum<\/jats:italic> showed anorexia, loss of weight, diarrhoea and macroscopically obvious oedema and inflammation of the alimentary tract. Arthus-like lesions caused by the larvae developed particularly in the large intestine.<\/jats:p><jats:p>The gross immunological responses of the sheep were associated with antibodies in greater titre within the mucus of the gut than in the serum. Acquired immunity was manifest through an antibody-antigen reaction which was localized mostly in the large intestine and which involved proliferation of the lymphoid tissue of the gut and an increased synthesis of protein. Lower titres of antibody in serum than in mucus may indicate leakage of antibody away from the gut. The direct effects of antibody were established by the respiratory inhibition of the 3rd-stage larvae. The presence of antibody was associated with particularly high concentrations of \u03b2 globulin after first and \u03b2 and \u03b3 globulins after second infection. Specific antibody was demonstrated in these protein fractions by blockage of electrophoretic movement by larval antigen in the buffer.<\/jats:p><jats:p>The antibody-antigen reaction may act as a trigger which releases the nonspecific effects of excess mucus production and oedema which causes mechanical dislodgement of the infection. The natural and specific respiratory inhibitory effects of mucus on the worm would facilitate this dislodgement process.<\/jats:p><jats:p>The greatest cellular reactions occurred where there was an active infection. Usually these reactions were associated with oedema, hyperaemia and an increase in the size of the mesenteric lymph nodes.<\/jats:p>","DOI":"10.1017\/s0031182000072036","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T17:22:21Z","timestamp":1244222541000},"page":"201-219","source":"Crossref","is-referenced-by-count":26,"title":["Changes in the protein content of the serum and intestinal mucus of sheep with reference to the histology of the gut and immunological response to <i>Oesophagostomum columbianum<\/i> infections"],"prefix":"10.1017","volume":"57","author":[{"given":"Colin","family":"Dobson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000072036_ref003","first-page":"195","article-title":"The mast cell: Its structure and function","volume":"8","author":"Benditt","year":"1964","journal-title":"Prog. 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