{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T15:53:20Z","timestamp":1697039600213},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":6031,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1992,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Trickle infections with a hamster-adapted strain of the hookworm<jats:italic>Ancylostoma ceylanicum<\/jats:italic>were studied by administering doses of 5\u201330 larvae twice weekly to inbred DSN hamsters. The worm burdens were regulated at very low levels, and this was found to be independent of the size of the infective dose. It is likely that there is some turnover of adult worms during trickle infection, as larvae of all stages were recovered from most time-points. This regulation is immunologically mediated and both the worm burdens and fecundity were increased in hamsters that were immunosuppressed by cortisone treatment. A trickle infection regime also induced a 67% protective immunity to a single subsequent challenge. The resistance that occurred during trickle infections was, however, incomplete, and some worms were found to survive in hamsters that had been repeatedly infected for over 10 weeks. Thus, although hamsters are capable of regulating the infection, some worms are capable of surviving the host immune effectors.<\/jats:p>","DOI":"10.1017\/s0031182000074175","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:17:54Z","timestamp":1244211474000},"page":"247-253","source":"Crossref","is-referenced-by-count":15,"title":["The dynamics of trickle infections with<i>Ancylostoma ceylanicum<\/i>in inbred hamsters"],"prefix":"10.1017","volume":"105","author":[{"given":"T. J.","family":"Brailsford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Behnke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000074175_ref012","first-page":"157","volume-title":"Biology and Control of Endoparasites","author":"Donald","year":"1982"},{"key":"S0031182000074175_ref013","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200006220X"},{"key":"S0031182000074175_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(85)90128-2"},{"key":"S0031182000074175_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(85)90030-X"},{"key":"S0031182000074175_ref011","doi-asserted-by":"publisher","DOI":"10.1038\/315491a0"},{"key":"S0031182000074175_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(72)90038-0"},{"key":"S0031182000074175_ref023","volume-title":"Statistics Using Ranks, a Unified Approach","author":"Meddis","year":"1984"},{"key":"S0031182000074175_ref002","first-page":"190","article-title":"Experimental infection of Ancylostoma ceylanicum in man","volume":"53","author":"Areekul","year":"1970","journal-title":"Journal of the Medical Association of Thailand"},{"key":"S0031182000074175_ref019","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200007760X"},{"key":"S0031182000074175_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(05)80013-X"},{"key":"S0031182000074175_ref016","first-page":"181","article-title":"Immunological responses of hamsters to Ancylostoma ceylanicum infection","volume":"22","author":"Gupta","year":"1985","journal-title":"Helminthologia"},{"key":"S0031182000074175_ref030","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1986.0075"},{"key":"S0031182000074175_ref029","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0034-5288(18)31152-4","article-title":"Development of immunity to incoming radiolabelled larvae in lambs continuously infected with Ostertagia circumcincta","volume":"46","author":"Seaton","year":"1989","journal-title":"Research in Veterinary Science"},{"key":"S0031182000074175_ref003","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0300-5089(21)00200-5","article-title":"Hookworm","volume":"7","author":"Banwell","year":"1978","journal-title":"Clinical Gastroenterology"},{"key":"S0031182000074175_ref028","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0034-5288(18)31111-1","article-title":"Development of immunity to incoming radiolabelled larvae in lambs continuously infected with Trichostrongylus vitrinus","volume":"46","author":"Seaton","year":"1989","journal-title":"Research in Veterinary Science"},{"key":"S0031182000074175_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(87)90060-3"},{"key":"S0031182000074175_ref022","first-page":"268","article-title":"Immunity reactions of the dog against hookworm (Ancylostoma caninum) under conditions of repeated infection","volume":"14","author":"McCoy","year":"1931","journal-title":"American Journal of Hygiene"},{"key":"S0031182000074175_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(85)90049-9"},{"key":"S0031182000074175_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000046382"},{"key":"S0031182000074175_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/S0368-1742(64)80050-3"},{"key":"S0031182000074175_ref014","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00009068"},{"key":"S0031182000074175_ref015","first-page":"822","article-title":"Selective primary health care: Strategies for control of disease in the developing world. XVII. Hookworm infection and anaemia","volume":"4","author":"Gilles","year":"1985","journal-title":"Reviews of Infectious Diseases"},{"key":"S0031182000074175_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(85)90084-7"},{"key":"S0031182000074175_ref017","first-page":"65","article-title":"New technique for obtaining nematode ova from sheep faeces","volume":"23","author":"Jackson","year":"1974","journal-title":"Laboratory Practice"},{"key":"S0031182000074175_ref018","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0034-5288(18)32227-6","article-title":"Development of morphological changes in the small intestine of lambs continuously infected with Trichostrongylus vitrinus","volume":"34","author":"Jackson","year":"1983","journal-title":"Research in Veterinary Science"},{"key":"S0031182000074175_ref021","unstructured":"Maema M. (1986). Dynamics of repeated infection of high and low responder inbred mice with Heligmosomoides polygyrus. Ph.D. thesis, Imperial College, London."},{"key":"S0031182000074175_ref024","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00025815"},{"key":"S0031182000074175_ref026","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000041287"},{"key":"S0031182000074175_ref027","doi-asserted-by":"publisher","DOI":"10.1007\/BF01928740"},{"key":"S0031182000074175_ref031","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000044528"},{"key":"S0031182000074175_ref032","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(78)90091-7"},{"key":"S0031182000074175_ref033","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1968.17.378"},{"key":"S0031182000074175_ref025","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000031127"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000074175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T23:08:18Z","timestamp":1633561698000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000074175\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,10]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,10]]}},"alternative-id":["S0031182000074175"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000074175","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,10]]}}}