{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T22:23:41Z","timestamp":1743805421891},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":6031,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1992,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The present study compares parasite-specific antibody responses in two Caribbean communities with high and low levels of<jats:italic>Trichuris trichiura<\/jats:italic>transmission. The age-dependency of antibody levels suggest that IgG<jats:sub>1<\/jats:sub>and IgG<jats:sub>2<\/jats:sub>levels relate to the current intensity of infection (as assessed by density of eggs in stool (e.p.g.) and reflect the age\u2013intensity profile at the population level. IgG<jats:sub>4<\/jats:sub>, IgE and IgA levels persist into early adulthood and the subsequent decline is gradual. In the low transmission area, lower infection levels are reflected in lower parasite-specific antibody levels (of all isotypes) in the community as a whole. Despite a significantly greater past experience of infection in the high transmission area, antibody levels are not maintained at significantly higher levels throughout adulthood. The production of IgA appears to require a threshold for triggering, and a vigorous IgA response is maintained into early adulthood only in the high transmission village where peak intensity is greatest and the age-convexity of intensity is most marked. Experimental and theoretical studies focusing on the dynamic nature of host\u2013helminth interactions in hosts exposed to high and low infection levels, and the putative role of acquired immunity, are discussed in relation to the data presented.<\/jats:p>","DOI":"10.1017\/s0031182000074205","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:17:54Z","timestamp":1244211474000},"page":"273-283","source":"Crossref","is-referenced-by-count":33,"title":["The relationship between<i>Trichuris trichiura<\/i>transmission intensity and the age-profiles of parasite-specific antibody isotypes in two endemic communities"],"prefix":"10.1017","volume":"105","author":[{"given":"C. S.","family":"Needham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A. P.","family":"Bundy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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