{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:10:13Z","timestamp":1791223813016,"version":"4.1.0"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":5454,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1994,5]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The question of whether the known immunosuppressive effects of <jats:italic>Babesia microti<\/jats:italic> may disrupt the development of acquired resistance to its tick vector, <jats:italic>Ixodes trianguliceps<\/jats:italic>, in natural rodent hosts (<jats:italic>Clethrionomys glareolus<\/jats:italic>), and thus enhance thedisease transmission potential, is addressed experimentally. The results show for the first time that natural hosts can acquire resistance to ticks; that this acquired resistance is manifested chiefly by a strongly density-dependent reduction in the percentage of attached larvae that engorge; that the density dependence is quantitatively similar whether the host receives occasional large tick challenges or frequent low infestations; but that infection with <jats:italic>B. microti<\/jats:italic> does not disrupt this pattern of acquired resistance. Of two important natural host species, <jats:italic>Apodemus sylvaticus<\/jats:italic> can support repeated infestations of <jats:italic>I. trianguliceps<\/jats:italic>, but is a poor host to <jats:italic>B. microti<\/jats:italic>, while <jats:italic>C. glareolus<\/jats:italic> develops acquired resistance to the tickvector, but supports much higher-level, longer-lasting <jats:italic>B. microti<\/jats:italic> infections.<\/jats:p>","DOI":"10.1017\/s003118200007596x","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:00:10Z","timestamp":1244210410000},"page":"413-419","source":"Crossref","is-referenced-by-count":58,"title":["Density-dependent acquired resistance to ticks in natural hosts, independent of concurrent infection with <i>Babesia microti<\/i>"],"prefix":"10.1017","volume":"108","author":[{"given":"S. E.","family":"Randolph","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S003118200007596X_ref024","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2307\/3272160","article-title":"Acquired immunity to ticks","volume":"25","author":"Tracer","year":"1939","journal-title":"Journal of Parasitology"},{"key":"S003118200007596X_ref020","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2915.1987.tb00340.x"},{"key":"S003118200007596X_ref017","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000052033"},{"key":"S003118200007596X_ref014","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200006234X"},{"key":"S003118200007596X_ref010","doi-asserted-by":"publisher","DOI":"10.1126\/science.3616608"},{"key":"S003118200007596X_ref006","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2915.1992.tb00614.x"},{"key":"S003118200007596X_ref002","doi-asserted-by":"publisher","DOI":"10.1038\/272818a0"},{"key":"S003118200007596X_ref028","unstructured":"Young A. S. (1970). Investigations on the epidemiology of blood parasites of small mammals with special reference to piroplasms. Ph.D. thesis, University of London."},{"key":"S003118200007596X_ref026","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1985.11811977"},{"key":"S003118200007596X_ref022","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2915.1993.tb00673.x"},{"key":"S003118200007596X_ref016","doi-asserted-by":"publisher","DOI":"10.2307\/3606"},{"key":"S003118200007596X_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(76)90015-1"},{"key":"S003118200007596X_ref007","doi-asserted-by":"publisher","DOI":"10.2307\/3282875"},{"key":"S003118200007596X_ref004","first-page":"146","volume-title":"Parasites, Immunity and Pathology: the Consequences of Parasitic Infection in Mammals","author":"Clark","year":"1990"},{"key":"S003118200007596X_ref021","doi-asserted-by":"publisher","DOI":"10.1007\/BF01200449"},{"key":"S003118200007596X_ref009","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1980.11687381"},{"key":"S003118200007596X_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(88)90080-5"},{"key":"S003118200007596X_ref025","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000051453"},{"key":"S003118200007596X_ref023","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(90)90338-5"},{"key":"S003118200007596X_ref019","first-page":"495","article-title":"Naturally acquired resistance to ticks \u2013 a global view","volume":"13","author":"Rechav","year":"1992","journal-title":"Insect Science and its Application"},{"key":"S003118200007596X_ref018","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000060285"},{"key":"S003118200007596X_ref003","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/1950255474"},{"key":"S003118200007596X_ref015","doi-asserted-by":"publisher","DOI":"10.2307\/3605"},{"key":"S003118200007596X_ref012","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2915.1993.tb00674.x"},{"key":"S003118200007596X_ref005","first-page":"129","volume-title":"Second International Symposium on the Biochemistry of Parasites and Host\u2013Parasite Relationships","author":"Cox","year":"1976"},{"key":"S003118200007596X_ref011","doi-asserted-by":"publisher","DOI":"10.1007\/BF02124302"},{"key":"S003118200007596X_ref027","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(86)90098-1"},{"key":"S003118200007596X_ref008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1983.tb00730.x"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S003118200007596X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T04:10:00Z","timestamp":1557893400000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S003118200007596X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,5]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,5]]}},"alternative-id":["S003118200007596X"],"URL":"https:\/\/doi.org\/10.1017\/s003118200007596x","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,5]]}}}