{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:33:53Z","timestamp":1778895233859,"version":"3.51.4"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":5574,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Parasitological and immunological interactions between <jats:italic>Eimeria vermiformis<\/jats:italic> or <jats:italic>E. pragensis<\/jats:italic> and <jats:italic>Trichinella spiralis<\/jats:italic> were investigated during concurrent infections in NIH, BALB\/c and B10.G inbred mice. The establishment of <jats:italic>T. spiralis<\/jats:italic> was unaffected by the presence of either coccidium, but expulsion of adult worms was delayed significantly in mice infected with <jats:italic>E. vermiformis; E. pragensis<\/jats:italic> did not have this effect. Replication of <jats:italic>E. vermiformis<\/jats:italic> was enhanced in concurrent infections with <jats:italic>T. spiralis<\/jats:italic>, but that of <jats:italic>E. pragensis<\/jats:italic> was reduced. Specific immune responses to each parasite were unaffected in mice infected with <jats:italic>T. spiralis<\/jats:italic> and <jats:italic>E. pragensis<\/jats:italic>, but levels of some responses were reduced when <jats:italic>T. spiralis<\/jats:italic> and <jats:italic>E. vermiformis<\/jats:italic> were combined. Thus both <jats:italic>in vitro<\/jats:italic> antigen-induced proliferation of mesenteric lymph node cells (MLNC) and intestinal mastocytosis were lower than in singly infected mice. Mitogen (Con A) responsiveness of MLNC was not affected in mice infected with <jats:italic>T. spiralis<\/jats:italic> and <jats:italic>E. vermiformis<\/jats:italic>, and cells from these mice were capable of transferring protective immunity to the nematode in naive recipients. Injection of monoclonal antibody to interferon gamma, a major component of the cytokine response to <jats:italic>E. vermiformis<\/jats:italic>, did not prevent delay of worm expulsion in concurrent infections. The results are discussed in terms of possible interactions between the T helper cell subsets or the inflammatory components of the responses induced by each parasite.<\/jats:p>","DOI":"10.1017\/s0031182000078537","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T10:03:53Z","timestamp":1244196233000},"page":"69-75","source":"Crossref","is-referenced-by-count":11,"title":["Interactions between infections with <i>Eimeria<\/i> spp. and <i>Trichinella spiralis<\/i> in inbred mice"],"prefix":"10.1017","volume":"108","author":[{"given":"M. E.","family":"Roses","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Wakelin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Hesketh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000078537_ref005","doi-asserted-by":"publisher","DOI":"10.2307\/3279613"},{"key":"S0031182000078537_ref022","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1993.tb00567.x"},{"key":"S0031182000078537_ref009","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000044929"},{"key":"S0031182000078537_ref008","first-page":"329","article-title":"Host protective immunity to Trichinella spiralis in mice: activation of Th cell subsets and lymphokine secretion in mice expressing different response phenotypes","volume":"74","author":"Grencis","year":"1991","journal-title":"Immunology"},{"key":"S0031182000078537_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(90)90032-8"},{"key":"S0031182000078537_ref015","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1991.tb00263.x"},{"key":"S0031182000078537_ref007","first-page":"213","article-title":"L3T4-positive T lymphoblasts are responsible for transfer of immunity to Trichinella spiralis in mice","volume":"56","author":"Grencis","year":"1985","journal-title":"Immunology"},{"key":"S0031182000078537_ref021","first-page":"281","volume-title":"Coccidiosis of Man and Domestic Animals","author":"Wakelin","year":"1990"},{"key":"S0031182000078537_ref017","first-page":"125","article-title":"Immunodepression in parasitic infections","volume":"27","author":"Terry","year":"1982","journal-title":"Fortschritte der Zoologie"},{"key":"S0031182000078537_ref001","doi-asserted-by":"publisher","DOI":"10.2307\/3281238"},{"key":"S0031182000078537_ref002","doi-asserted-by":"publisher","DOI":"10.2307\/3282404"},{"key":"S0031182000078537_ref003","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1984.tb02962.x"},{"key":"S0031182000078537_ref004","doi-asserted-by":"publisher","DOI":"10.1136\/vr.124.23.603"},{"key":"S0031182000078537_ref006","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1978.tb04400.x"},{"key":"S0031182000078537_ref010","doi-asserted-by":"publisher","DOI":"10.1007\/BF02007723"},{"key":"S0031182000078537_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(82)90015-0"},{"key":"S0031182000078537_ref012","doi-asserted-by":"publisher","DOI":"10.2307\/3281850"},{"key":"S0031182000078537_ref013","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1983.tb00762.x"},{"key":"S0031182000078537_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(80)90013-2"},{"key":"S0031182000078537_ref019","first-page":"108","volume-title":"Allergy and Immunity to Helminths","author":"Wakelin","year":"1992"},{"key":"S0031182000078537_ref020","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000048472"},{"key":"S0031182000078537_ref018","doi-asserted-by":"publisher","DOI":"10.2307\/3282082"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000078537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T15:44:51Z","timestamp":1557935091000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000078537\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["S0031182000078537"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000078537","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}