{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:48:03Z","timestamp":1761155283135},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":5574,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The present study examines the role of host genetics in predisposition to <jats:italic>Ascaris lumbricoides<\/jats:italic> and <jats:italic>Trichuris trichiura<\/jats:italic> infection, by comparing the associations between age-standardized infection intensities of parents and their children (genetically related), with age-standardized infection intensities of parents alone (not related), within families previously demonstrated to exhibit familial predisposition. The lack of a consistent trend in infection intensity associations within families, in particular the lack of a stronger association between parents and their children than between unrelated parents, suggests that host genetic factors are not a major determinant of infection status. If there is a genetic basis for predisposition, then the data suggest that the effects of this genetic basis are overwhelmed by other, environmental or behavioural features of the family household.<\/jats:p>","DOI":"10.1017\/s0031182000078549","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:03:53Z","timestamp":1244210633000},"page":"77-80","source":"Crossref","is-referenced-by-count":32,"title":["Genetic relatedness as a determinant of predisposition to <i>Ascaris lumbricoides<\/i> and <i>Trichuris trichiura<\/i> infection"],"prefix":"10.1017","volume":"108","author":[{"given":"L.","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A. P.","family":"Bundy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. P.","family":"Kan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000078549_ref015","volume-title":"Ecological Methods with Particular Reference to the Study of Insect Populations","author":"Southwood","year":"1978"},{"key":"S0031182000078549_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(85)90101-2"},{"key":"S0031182000078549_ref007","article-title":"Aggregation and predisposition to Ascaris lumbricoides and Trichuris trichiura at the familial level","author":"Chan","year":"1993","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"S0031182000078549_ref002","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1988.0100"},{"key":"S0031182000078549_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(88)90448-8"},{"key":"S0031182000078549_ref001","first-page":"959","article-title":"Evidence for the segregation of a major gene in human susceptibility\/resistance to infection by Schistosoma mansoni","volume":"48","author":"Abel","year":"1991","journal-title":"American Journal of Human Genetics"},{"key":"S0031182000078549_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800061719"},{"key":"S0031182000078549_ref004","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000075284"},{"key":"S0031182000078549_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(85)90178-6"},{"key":"S0031182000078549_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000061837"},{"key":"S0031182000078549_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(90)90284-L"},{"key":"S0031182000078549_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91593-W"},{"key":"S0031182000078549_ref011","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000057772"},{"key":"S0031182000078549_ref012","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200005873X"},{"key":"S0031182000078549_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(89)90122-1"},{"key":"S0031182000078549_ref014","first-page":"177","volume-title":"Hookworm Disease: Current Status and New Directions","author":"Keymer","year":"1990"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000078549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T19:44:58Z","timestamp":1557949498000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000078549\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["S0031182000078549"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000078549","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}