{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T17:17:17Z","timestamp":1721841437851},"reference-count":47,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":6884,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1990,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Neonatal hamsters were exposed to varying doses of<jats:italic>Necator americanus<\/jats:italic>larvae and changes in the stability of the resulting worm burdens were monitored over a period of 25 weeks. No change in worm burdens was evident for the first 5 weeks of infection, irrespective of the infection intensity, but the more heavily infected groups subsequently lost worms in a density-dependent manner. Male and female hamsters lost comparable proportions of their established parasite burdens indicating that there was no host sex-linked difference in this respect. By week 15 infections had stabilized and the residual worm burdens, usually a maximum of 30 worms survived for a considerably longer period of time. Initially the percentage of male worms varied from 45% to 50% but as infection progressed male worms comprised a significantly increasing proportion of the total worm burden. By week 25 the percentage of male worms was usually in excess of 60%. The growth of infected animals was not severely affected by<jats:italic>N. americanus<\/jats:italic>, even when heavy worm burdens established initially, but a significant effect was detected particularly in week 5, prior to worm loss, when the adult worms would have been feeding on intestinal tissues and causing blood loss for a period of about 2 weeks. The most severe depression in the packed cell volume was also recorded in week 5, indicating that anaemia had been initiated in infected hamsters. Whilst, the regulation of parasite burdens in weeks 5\u201310 post-infection may have resulted from host immunity, the persistence of the residual worm burdens, the marked density-dependent anaemia and the subtle effect on host weight, all reflected well-documented aspects of chronic human necatoriasis.<\/jats:p>","DOI":"10.1017\/s0031182000078781","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:40:43Z","timestamp":1244212843000},"page":"469-478","source":"Crossref","is-referenced-by-count":8,"title":["<i>Necator americanus<\/i>in the DSN hamster: density-dependent expulsion of adult worms during primary infection"],"prefix":"10.1017","volume":"100","author":[{"given":"R. A.","family":"Rose","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Behnke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000078781_ref046","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(89)90010-6"},{"key":"S0031182000078781_ref045","first-page":"7","volume-title":"Hookworm disease: proportion of males to females in the American hookworm (Necator americanus) based on 13,080 worms from 102 cases","volume":"28","author":"Stiles","year":"1913"},{"key":"S0031182000078781_ref044","volume-title":"Biometry","author":"Sokal","year":"1969"},{"key":"S0031182000078781_ref041","doi-asserted-by":"publisher","DOI":"10.2307\/3276401"},{"key":"S0031182000078781_ref040","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1966.15.1032"},{"key":"S0031182000078781_ref038","first-page":"169","article-title":"The topographic distribution of Necator americanus and Ancylostoma duodenale in the human intestine","volume":"27","author":"Rep","year":"1975","journal-title":"Tropical and Geographical Medicine"},{"key":"S0031182000078781_ref037","first-page":"227","article-title":"The pathogenicity of Ancylostoma braziliense. III. Distribution and migration of a hookworm population in its host","volume":"18","author":"Rep","year":"1966","journal-title":"Tropical and Geographical Medicine"},{"key":"S0031182000078781_ref032","first-page":"444","article-title":"A comparative study of Nippostrongylus muris in rats and mice","volume":"22","author":"Porter","year":"1935","journal-title":"American Journal of Hygiene"},{"key":"S0031182000078781_ref031","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1955.4.756"},{"key":"S0031182000078781_ref030","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1978.27.1162"},{"key":"S0031182000078781_ref029","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1978.27.1152"},{"key":"S0031182000078781_ref025","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000061540"},{"key":"S0031182000078781_ref023","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1981.11687444"},{"key":"S0031182000078781_ref022","doi-asserted-by":"publisher","DOI":"10.1038\/337114a0"},{"key":"S0031182000078781_ref020","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000028924"},{"key":"S0031182000078781_ref018","first-page":"574","article-title":"Site selection by parasitic helminths: interspecific interactions, site segregation and their importance to the development of the helminth communities","volume":"51","author":"Holmes","year":"1973","journal-title":"Canadian Journal of Parasitology"},{"key":"S0031182000078781_ref016","doi-asserted-by":"publisher","DOI":"10.2307\/3275400"},{"key":"S0031182000078781_ref015","doi-asserted-by":"publisher","DOI":"10.1111\/j.2164-0947.1973.tb01971.x"},{"key":"S0031182000078781_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(89)90209-3"},{"key":"S0031182000078781_ref012","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/150.2.284"},{"key":"S0031182000078781_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(88)90076-2"},{"key":"S0031182000078781_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(86)90080-9"},{"key":"S0031182000078781_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(87)90367-1"},{"key":"S0031182000078781_ref006","volume-title":"Hookworm Disease: Current Status and New Directions","author":"Behnke","year":"1990"},{"key":"S0031182000078781_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(87)90060-3"},{"key":"S0031182000078781_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(86)90007-1"},{"key":"S0031182000078781_ref047","first-page":"343","article-title":"Genetic control of immunity to Trichinella spiralis: influence of H-2 linked genes on immunity to the intestinal phase of infection","volume":"48","author":"Wakelin","year":"1983","journal-title":"Immunology"},{"key":"S0031182000078781_ref043","doi-asserted-by":"publisher","DOI":"10.1038\/214609b0"},{"key":"S0031182000078781_ref024","volume-title":"Biochemistry of Parasites and Host\u2013Parasite Relationships","author":"Lee","year":"1976"},{"key":"S0031182000078781_ref026","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60552-7"},{"key":"S0031182000078781_ref042","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(72)90006-9"},{"key":"S0031182000078781_ref028","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(85)90090-6"},{"key":"S0031182000078781_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(68)90053-2"},{"key":"S0031182000078781_ref017","first-page":"128","volume-title":"Impact of Helminth Infections on Human Nutrition (Stephenson, L. S.)","author":"Holland","year":"1987"},{"key":"S0031182000078781_ref036","first-page":"354","article-title":"A new system for the diagnosis of Ancylostomidae, especially the human hookworm species","volume":"16","author":"Rep","year":"1964","journal-title":"Tropical and Geographical Medicine"},{"key":"S0031182000078781_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60561-8"},{"key":"S0031182000078781_ref004","doi-asserted-by":"publisher","DOI":"10.2307\/3276288"},{"key":"S0031182000078781_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(88)90077-4"},{"key":"S0031182000078781_ref014","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200006220X"},{"key":"S0031182000078781_ref003","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0300-5089(21)00200-5","article-title":"Hookworms","volume":"7","author":"Banwell","year":"1978","journal-title":"Clinics in Gastroenterology"},{"key":"S0031182000078781_ref021","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000052847"},{"key":"S0031182000078781_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(86)90216-6"},{"key":"S0031182000078781_ref027","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000071511"},{"key":"S0031182000078781_ref033","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1986.tb00852.x"},{"key":"S0031182000078781_ref035","doi-asserted-by":"publisher","DOI":"10.2307\/3273449"},{"key":"S0031182000078781_ref039","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(61)90040-6"},{"key":"S0031182000078781_ref034","first-page":"333","article-title":"Site of resistance to Necator americanus","volume":"42","author":"Rajasekariah","year":"1985","journal-title":"Acta Tropica"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000078781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T23:13:44Z","timestamp":1633562024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000078781\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,6]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,6]]}},"alternative-id":["S0031182000078781"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000078781","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,6]]}}}