{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:10:15Z","timestamp":1790856615057,"version":"4.1.0"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":6884,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1990,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Strains of mice poorly (B10) or non-responsive (B10.BR) to a primary infection with<jats:italic>Trichuris muris<\/jats:italic>were protected against infection by vaccination with excretory\/secretory (E\/S) antigen in Complete Freund's Adjuvant (CFA). Protection in these mice was slow to be expressed compared to that in good responder strains. Vaccination boosted the IgG and IgG1 antibody responses to E\/S antigen and altered the antigen recognition profiles, three high molecular weight antigens (80\u201385, 90\u201395, 105\u2013110 kDa) being recognized by antibodies in sera from vaccinated but not control mice. B10. BR mice which had experienced a patent primary infection could not be protected against challenge infections by vaccination and this was correlated with depressed levels of IgG1, but not total IgG, to E'S antigen early post-challenge compared with vaccinated infected mice which had not seen an adult primary infection. There was also lack of recognition of the three high molecular weight antigens recognized by antibodies in sera from mice infected after vaccination. It is suggested that the rapid development of high levels of IgG1 antibodies, and the recognition of the three high molecular weight antigens, may reflect events that are important in protective immunity. Immunomodulation of host immunity by<jats:italic>T. muris<\/jats:italic>may therefore be achieved, at least in part, by the suppression of specific IgG1 levels, the production of an irrelevant IgG isotype and prevention of the recognition of critical antigens.<\/jats:p>","DOI":"10.1017\/s0031182000078793","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:40:43Z","timestamp":1244212843000},"page":"479-489","source":"Crossref","is-referenced-by-count":24,"title":["Genetically-determined influences on the ability of poor responder mice to respond to immunization against<i>Trichuris muris<\/i>"],"prefix":"10.1017","volume":"100","author":[{"given":"K. J.","family":"Else","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Wakelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000078793_ref032","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(73)90061-1"},{"key":"S0031182000078793_ref030","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000078070"},{"key":"S0031182000078793_ref026","doi-asserted-by":"publisher","DOI":"10.1038\/336481a0"},{"key":"S0031182000078793_ref023","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198004103021503"},{"key":"S0031182000078793_ref021","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1984.14"},{"key":"S0031182000078793_ref017","doi-asserted-by":"publisher","DOI":"10.1159\/000232624"},{"key":"S0031182000078793_ref015","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.4049\/jimmunol.135.3.2102","article-title":"Prophylactic immunization against experimental leishmaniasis. V. Mechanism of the anti-protective blocking effect induced by subcutaneous immunization against Leishmania major infection","volume":"135","author":"Liew","year":"1985","journal-title":"Journal of Immunology"},{"key":"S0031182000078793_ref014","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.4049\/jimmunol.135.3.2095","article-title":"Prophylactic immunization against experimental leishmaniasis. IV. Subcutaneous immunization prevented the induction of protective immunity against fatal Leishmania major infection","volume":"135","author":"Liew","year":"1985","journal-title":"Journal of Immunology"},{"key":"S0031182000078793_ref013","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.4049\/jimmunol.137.8.2700","article-title":"Interleukin inhibition by a parasite proteinase inhibitor, taeniaestatin","volume":"137","author":"Leid","year":"1986","journal-title":"Journal of Immunology"},{"key":"S0031182000078793_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(89)90172-2"},{"key":"S0031182000078793_ref010","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000057188"},{"key":"S0031182000078793_ref009","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000047648"},{"key":"S0031182000078793_ref007","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.2.302"},{"key":"S0031182000078793_ref004","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000080173"},{"key":"S0031182000078793_ref029","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000072395"},{"key":"S0031182000078793_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000062193"},{"key":"S0031182000078793_ref028","doi-asserted-by":"publisher","DOI":"10.1084\/jem.162.5.1726"},{"key":"S0031182000078793_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(89)90021-0"},{"key":"S0031182000078793_ref005","first-page":"77","article-title":"Genetic variation in the humoral immune responses of mice to the nematode Trichuris muris","volume":"11","author":"Else","year":"1989","journal-title":"Parasitology"},{"key":"S0031182000078793_ref027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1988.tb00741.x"},{"key":"S0031182000078793_ref022","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(89)90030-1"},{"key":"S0031182000078793_ref008","unstructured":"Jenkins S. N. (1977). Studies on the immune response of the mouse to the nematode Trichuris muris. Ph.D. thesis, University of Glasgow."},{"key":"S0031182000078793_ref001","doi-asserted-by":"crossref","first-page":"781","DOI":"10.4049\/jimmunol.95.5.781","article-title":"The immunoglobulins of mice. VI. Response to immunization","volume":"95","author":"Barth","year":"1965","journal-title":"Journal of Immunology"},{"key":"S0031182000078793_ref020","first-page":"211","volume-title":"Genetic Control of Host Resistance to Infection and Malignancy","author":"Mitchell","year":"1985"},{"key":"S0031182000078793_ref031","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000053142"},{"key":"S0031182000078793_ref018","doi-asserted-by":"publisher","DOI":"10.1159\/000234835"},{"key":"S0031182000078793_ref016","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurements with the folin-phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"Journal of Biological Chemistry"},{"key":"S0031182000078793_ref025","first-page":"633","article-title":"Analysis of the mechanisms of immunodepression following heterologous antigenic stimulation during concurrent infection with Nematospiroides dubius","volume":"51","author":"Pritchard","year":"1984","journal-title":"Immunology"},{"key":"S0031182000078793_ref002","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.8.4066"},{"key":"S0031182000078793_ref019","doi-asserted-by":"publisher","DOI":"10.1159\/000234080"},{"key":"S0031182000078793_ref024","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X0000804X"},{"key":"S0031182000078793_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(89)90246-6"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000078793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T09:04:11Z","timestamp":1710407051000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000078793\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,6]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,6]]}},"alternative-id":["S0031182000078793"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000078793","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,6]]}}}