{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T15:10:44Z","timestamp":1685027444201},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":6823,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1990,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>In common with other taeniid cestodes, host or host-like proteins, especially immunoglobulins, occur on the surface and in the cyst fluid of<jats:italic>Taenia crassiceps metacestodes<\/jats:italic>. Here, several approaches have been used to determine the origin of the immunoglobulins present on the tegument. Indirect IFAT showed that IgG was almost totally lost from the surface of bladders after 6 days culture<jats:italic>in vitro<\/jats:italic>. There was a rapid reacquisition of immunoglobulins following incubation of the cultured metacestodes with either normal mouse serum or mouse anti-<jats:italic>T. crassiceps<\/jats:italic>antiserum. Immunoprecipitation of<jats:italic>in vitro<\/jats:italic>translation products and biosynthetically labelled<jats:italic>T. crassiceps<\/jats:italic>proteins with a panel of anti-IgG antisera failed to positively identify any molecule with homology to mammalian immunoglobulins. These results suggest strongly that the immunoglobulins located on the surface of<jats:italic>T. crassiceps<\/jats:italic>are of host rather than parasite origin. The occurrence of a relatively low abundance receptor in the surface of the bladders, which binds non-specific host immunoglobulin, together with surface-bound specific anti-<jats:italic>T. crassiceps<\/jats:italic>antibodies can account for the presence of these host proteins. Freshly obtained bladders and metacestodes cultured in vitro for 6 days were transplanted into naive mice and the survival and development of the resulting parasites compared. In some individual mice there was a decrease in the number and volume of metacestodes and an increase in encapsulated parasites arising from cultured bladders. This was probably not related to the loss of host immunoglobulins from the parasite surface during culture as the reacquisition of these proteins after transplantation is likely to be far more rapid than any immune response could evoke in a naive host.<\/jats:p>","DOI":"10.1017\/s003118200007983x","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:39:37Z","timestamp":1244212777000},"page":"127-137","source":"Crossref","is-referenced-by-count":7,"title":["<i>Taenia crassiceps<\/i>surface immunoglobulins: parasite- or host-derived?"],"prefix":"10.1017","volume":"101","author":[{"given":"D. P.","family":"McManus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lamsam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S003118200007983X_ref025","doi-asserted-by":"publisher","DOI":"10.1038\/278447a0"},{"key":"S003118200007983X_ref022","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511525841"},{"key":"S003118200007983X_ref026","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.9.4350"},{"key":"S003118200007983X_ref006","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1988.tb00218.x"},{"key":"S003118200007983X_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(86)90094-4"},{"key":"S003118200007983X_ref024","doi-asserted-by":"crossref","first-page":"379","DOI":"10.4049\/jimmunol.126.1.379","article-title":"Demonstration of IgG-Fc and C3 receptors on adult Schistosoma mansoni","volume":"126","author":"Tarleton","year":"1981","journal-title":"Journal of Immunology"},{"key":"S003118200007983X_ref008","doi-asserted-by":"publisher","DOI":"10.2307\/3282338"},{"key":"S003118200007983X_ref001","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1988.tb00234.x"},{"key":"S003118200007983X_ref027","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2307\/3279461","article-title":"Cytochemical characterization of tegument membrane-associated carbohydrate in Taenia crassiceps larvae","volume":"61","author":"Trimble","year":"1975","journal-title":"Journal of Parasitology"},{"key":"S003118200007983X_ref002","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00007550"},{"key":"S003118200007983X_ref028","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(77)90046-7"},{"key":"S003118200007983X_ref005","doi-asserted-by":"publisher","DOI":"10.1021\/bi00591a005"},{"key":"S003118200007983X_ref023","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(73)90003-X"},{"key":"S003118200007983X_ref018","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000085516"},{"key":"S003118200007983X_ref015","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00005046"},{"key":"S003118200007983X_ref017","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000079828"},{"key":"S003118200007983X_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X0003474X"},{"key":"S003118200007983X_ref004","unstructured":"Chew M. W. K. (1981). Taenia crassiceps: structure, developmental biology and host-parasite relationship. Ph.D. thesis, University of London."},{"key":"S003118200007983X_ref007","doi-asserted-by":"publisher","DOI":"10.1086\/282313"},{"key":"S003118200007983X_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(87)90102-5"},{"key":"S003118200007983X_ref010","first-page":"465","volume-title":"Cysticercosis: Present State of Knowledge and Perspectives","author":"D\u00edaz De Le\u00f3n","year":"1982"},{"key":"S003118200007983X_ref019","doi-asserted-by":"publisher","DOI":"10.1007\/BF00328762"},{"key":"S003118200007983X_ref012","doi-asserted-by":"publisher","DOI":"10.2307\/3282918"},{"key":"S003118200007983X_ref013","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.4049\/jimmunol.115.6.1617","article-title":"Rapid isolation of antigens from cells with a Staphylococcal protein A-antibody absorbent: parameters of the interaction of antibody-antigen complexes with protein A","volume":"115","author":"Kessler","year":"1975","journal-title":"Journal of Immunology"},{"key":"S003118200007983X_ref014","doi-asserted-by":"publisher","DOI":"10.1007\/BF00535148"},{"key":"S003118200007983X_ref016","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"S003118200007983X_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(81)90129-6"},{"key":"S003118200007983X_ref021","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(79)90065-1"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S003118200007983X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T14:31:53Z","timestamp":1685025113000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S003118200007983X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,8]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,8]]}},"alternative-id":["S003118200007983X"],"URL":"https:\/\/doi.org\/10.1017\/s003118200007983x","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,8]]}}}