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Utilizing the negative binomial distribution as a description of observed aggregation, maximum-likelihood analysis reveals that the degree of aggregation is a negative linear function of mean worm burden. The factors responsible for this relationship in human populations require further study but may involve some combination of (i) density-dependent reduction in worm numbers within individuals, (ii) density-dependent parasite-induced host mortality or (iii) self-treatment by heavily infected hosts. Variability in the degree of aggregation appears dependent on the level of infection in a community and independent of geographical differences in the host or parasite populations.<\/jats:p>","DOI":"10.1017\/s0031182000079841","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:39:37Z","timestamp":1244212777000},"page":"139-143","source":"Crossref","is-referenced-by-count":79,"title":["The relationship between the frequency distribution of <i>Ascaris lumbricoides<\/i> and the prevalence and intensity of infection in human communities"],"prefix":"10.1017","volume":"101","author":[{"given":"H. L.","family":"Guyatt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A. P.","family":"Bundy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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