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Two of these antigens I<jats:sub>2<\/jats:sub>and I<jats:sub>17<\/jats:sub>are now characterized at the molecular level. Both exhibit a highly repetitive amino acid sequence organization, but they show no sequence similarity either to each other or to any other proteins known to date. Preliminary serological analyses indicate that both allow the early, sensitive and specific detection of infections with different species of trypanosomatids, making them interesting candidates for the development of diagnostic tools for trypanosomiasis detection.<\/jats:p>","DOI":"10.1017\/s0031182000080835","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T13:49:38Z","timestamp":1244209778000},"page":"249-258","source":"Crossref","is-referenced-by-count":36,"title":["Repetitive proteins from the flagellar cytoskeleton of African trypanosomes are diagnostically useful antigens"],"prefix":"10.1017","volume":"110","author":[{"given":"M.","family":"Imboden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hemphill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Mattioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Seebeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000080835_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0309-1651(88)90166-X"},{"key":"S0031182000080835_ref025","doi-asserted-by":"publisher","DOI":"10.2307\/3282427"},{"key":"S0031182000080835_ref024","doi-asserted-by":"publisher","DOI":"10.1126\/science.3393912"},{"key":"S0031182000080835_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(91)90185-9"},{"key":"S0031182000080835_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/1047-8477(91)90046-Y"},{"key":"S0031182000080835_ref017","doi-asserted-by":"publisher","DOI":"10.1126\/science.3142041"},{"key":"S0031182000080835_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(89)90115-1"},{"key":"S0031182000080835_ref012","first-page":"49","volume-title":"DNA Cloning 1","author":"Hyunh","year":"1985"},{"key":"S0031182000080835_ref026","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(88)90162-4"},{"key":"S0031182000080835_ref007","first-page":"1474","article-title":"Trypanosoma cruzii flagellar repetitive antigen expression by recombinant Baculovirus \u2013 towards an improved diagnostic reagent for Chagas disease","volume":"10","author":"Santos","year":"1992","journal-title":"Biotechnologys"},{"key":"S0031182000080835_ref022","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(90)90014-D"},{"key":"S0031182000080835_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(89)90005-4"},{"key":"S0031182000080835_ref019","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000067767"},{"key":"S0031182000080835_ref003","first-page":"289","article-title":"Cultivation and in vitro cloning of procyclic culture forms of Trypanosoma brucei in semi-defined medium","volume":"36","author":"Brun","year":"1979","journal-title":"Acta Tropica"},{"key":"S0031182000080835_ref015","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"S0031182000080835_ref006","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4049\/jimmunol.140.1.283","article-title":"Genetics of resistance to the African trypanosomes. 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