{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T12:28:38Z","timestamp":1779020918902,"version":"3.51.4"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":5209,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p>NIH and C57 BL\/10 (BIO) mice show genetically determined differences in their response to<jats:italic>Trichinella spiralis<\/jats:italic>infection. This study examines the influence of these on parameters of the immune response to infection after vaccination using muscle-larval excretory\u2013secretory antigen in Freund's complete adjuvant. Serum antibody levels were greatly elevated when mice of both strains were vaccinated prior to infection; however, NIH produced significantly higher-level antibody responses than B10. Vaccination accelerated and increased the capacity of mesenteric lymph node T-cells to proliferate<jats:italic>in vitro<\/jats:italic>in response to specific antigen stimulation in both mouse strains but, in general, the stimulation indices of NIH cells were higher than those of the B10. The capacity of mesenteric lymph node cells (MLNC) and spleen cells (SC) to produce IL-5 and \u03b3IFN was measured after specific<jats:italic>in vitro<\/jats:italic>stimulation and early \u03b3IFN secretion was noted in the supernatants of NIH MLNC and SC, but not in B10 SC. Concentrations of IL-S rose steadily over the first 10\u201314 days after infection in cell cultures from both strains. Prior vaccination of these animals appeared to enhance cytokine levels. It is postulated that the efficacy of vaccination in NIH mice is a consequence of their genetically determined capacity to produce early and high-level responses to the antigens of<jats:italic>T. spiralis<\/jats:italic>and to express these in intestinal effector mechanisms.<\/jats:p>","DOI":"10.1017\/s0031182000081063","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T13:53:06Z","timestamp":1244209986000},"page":"71-78","source":"Crossref","is-referenced-by-count":15,"title":["Immune response profiles in vaccinated and non-vaccinated high- and low-responder mice during infection with the intestinal nematode<i>Trichinella spiralis<\/i>"],"prefix":"10.1017","volume":"110","author":[{"given":"K.","family":"Robinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Bellaby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Wakelin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000081063_ref015","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1986.tb00842.x"},{"key":"S0031182000081063_ref014","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000048472"},{"key":"S0031182000081063_ref013","first-page":"153","volume-title":"Genetics of Resistance to Bacterial and Parasitic Infection","author":"Wakelin","year":"1988"},{"key":"S0031182000081063_ref012","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1990.tb00996.x"},{"key":"S0031182000081063_ref010","first-page":"261","article-title":"Vaccination against the nematode Trichinella spiralis in high- and low-responder mice. Effects of different adjuvants upon protective immunity and immune responsiveness","volume":"82","author":"Robinson","year":"1994","journal-title":"Immunology"},{"key":"S0031182000081063_ref017","doi-asserted-by":"publisher","DOI":"10.2307\/3280858"},{"key":"S0031182000081063_ref008","first-page":"278","volume-title":"Regulation of the Immune Response","author":"Mitchell","year":"1983"},{"key":"S0031182000081063_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000044929"},{"key":"S0031182000081063_ref004","first-page":"329","article-title":"Host protective immunity to Trichinella spiralis in mice: activation of Th subsets and lymphokine secretion in mice expressing different response phenotypes","volume":"74","author":"Grencis","year":"1991","journal-title":"Immunology"},{"key":"S0031182000081063_ref001","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000061059"},{"key":"S0031182000081063_ref016","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000047843"},{"key":"S0031182000081063_ref003","first-page":"508","article-title":"Cellular immune responses to the murine nematode parasite Trichuris muris. I Differential cytokine production during acute or chronic infection","volume":"72","author":"Else","year":"1991","journal-title":"Immunology"},{"key":"S0031182000081063_ref009","doi-asserted-by":"crossref","first-page":"957","DOI":"10.4049\/jimmunol.149.3.957","article-title":"Influence of resistant and susceptible genotype, IL-1, and lymphoid organ on Trichinella spiralis-induced cytokine secretion","volume":"149","author":"Pond","year":"1992","journal-title":"Journal of Immunology"},{"key":"S0031182000081063_ref005","doi-asserted-by":"crossref","first-page":"839","DOI":"10.4049\/jimmunol.129.2.839","article-title":"Antibody response to stage-specific Trichinella spiralis surface antigens in strong and weak responder mouse strains","volume":"129","author":"Jungery","year":"1982","journal-title":"Journal of Immunology"},{"key":"S0031182000081063_ref006","doi-asserted-by":"crossref","first-page":"306","DOI":"10.4049\/jimmunol.147.1.306","article-title":"\u03b3IFN- and IL-5-producing cells compartmentalize to different lymphoid organs in Trichinella spiralis-infected mice","volume":"147","author":"Kelly","year":"1991","journal-title":"Journal of Immunology"},{"key":"S0031182000081063_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(94)90065-5"},{"key":"S0031182000081063_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(90)90464-7"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000081063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T08:59:36Z","timestamp":1710406776000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000081063\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["S0031182000081063"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000081063","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}